Zu "K02677" wurden 192 Artikel gefunden!
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Phorbol 12-myristate 13-acetate
Artikelnummer: Cay10008014-1
Phorbol 12-myristate 13-acetate (PMA), also known as 12-O-tetradecanoylphorbol 13-acetate (TPA), is a phorbol ester and PKC activator. It activates the PKC isoforms PKCalpha, -beta, -gamma, -delta, -epsilon, -eta, and -theta but not PKCzeta or -iota/lambda. PMA (1-10 ng/ml) induces NF-kappaB-dependent gene...
| Schlagworte: | 12-O-Tetradecanoylphorbol-13-acetate, PMA, TPA, tetradecanoic acid,... |
| Anwendung: | PKC activator |
| CAS | 16561-29-8 |
| MW: | 616.8 D |
ab 50,00 €
Phorbol 12-myristate 13-acetate
Artikelnummer: AG-CN2-0010-M001
Most commonly-used phorbol ester, Binds to and activates protein kinase C (PKC) at nM concentrations, Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors...
| Schlagworte: | PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate |
| Anwendung: | PKC activator |
| CAS | 16561-29-8 |
| MW: | 616,8 D |
ab 44,00 €
Staurosporine
Artikelnummer: LKT-S7600.1
A protein kinase C inhibitor which induces apoptosis in many cell types. Experimental results obtained in a cell -free assay suggest that cytoplasmic proteins directly modulated by staurosporine may be involved in signaling the induction of DNA fragmentation and apoptosis.
| Schlagworte: | AM-2282, STS |
| Anwendung: | PKC inhibitor |
| CAS | 62996-74-1 |
| MW: | 466,5 D |
ab 60,00 €
Staurosporine
Artikelnummer: Cay81590-1
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-alpha approximately 100- and 1,000-fold better than PKC-delta and PKC-zeta, respectively. However, Stsp is non-selective in that it also inhibits the activity of a...
| Schlagworte: | Stsp,... |
| Anwendung: | PKC inhibitor |
| CAS | 62996-74-1 |
| MW: | 466.5 D |
ab 43,00 €
Tigilanol tiglate
Artikelnummer: TGM-T28975-25mg
Description: Tigilanol tiglate is a phorbol ester and acts as a protein kinase C regulator along with other related compounds. Target: Others. Smiles: O(C([C@H](CC)C)=O)[C@@]12[C@@](C1(C)C)([C@@]3([C@]4([C@](CO)(O4)[C@@H](O)[C@@]5(O)[C@]([C@@]3(O)[C@H](C)[C@H]2OC(/C(=C/C)/C)=O)(C=C(C)C5=O)[H])[H])[H])[H]....
| Schlagworte: | EBC-46, EBC 46, EBC46 |
| Anwendung: | Targets classical protein kinase C beta type [EC:2.7.11.13] (PRKCB) |
| CAS | 943001-56-7 |
| MW: | 562.65 D |
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Bisindolylmaleimide XI hydrochloride
Artikelnummer: TGM-T36228-1mg
Description: Bisindolylmaleimide XI hydrochloride is an orally active PKC inhibitor with inhibitory effects on PKCalpha, PKCbetaI, PKCbetaII, and PKCgamma (IC50s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM, respectively). Target: Others. Smiles: Cl.O=C1NC(=O)C(=C1C2=CN(C=3C=CC=CC23)C)C=4C=5C=CC=CC5N6C4CC(CN(C)C)CC6
| Anwendung: | PKC inhibitor |
| CAS | 145333-02-4 |
| MW: | 489.01 D |
210,00 €
Chelerythrine chloride
Artikelnummer: TGM-T3419-100mg
Description: Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Target: PKC, BCL, Apoptosis, Autophagy. Smiles: [Cl-].COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC. References: Chan, et al....
| Anwendung: | PKC inhibitor |
| CAS | 3895-92-9 |
| MW: | 383.83 D |
ab 62,00 €
Verbascoside
Artikelnummer: TGM-T3375-100mg
Description: Verbascoside (Kusaginin) is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities. Target: HSV, PKC, Apoptosis, Antibacterial, PARP, p53. Smiles: C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](OCCc3ccc(O)c(O)c3)O[C@H](CO)[C@H]2OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O....
| Schlagworte: | Kusaginin, TJC160, Acteoside |
| Anwendung: | Antiinflammatory, antibacterial, antitumor agent |
| CAS | 61276-17-3 |
| MW: | 624.59 D |
ab 57,00 €
Sphingosine (d14:1)
Artikelnummer: TGM-T38262-5mg
Description: Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fungus, with an EC50 value of 10.2 nM. Sphingosine (d14:1) inhibits protein kinase C...
| Anwendung: | Bioactive sphingolipid, PKC inhibitor |
| CAS | 24558-60-9 |
| MW: | 243.39 D |
540,00 €
Ruboxistaurin hydrochloride
Artikelnummer: TGM-T3689-100mg
Description: Ruboxistaurin hydrochloride (LY 333531 hydrochloride) is an Isozyme-selective inhibitor of protein kinase C (PKC), competitively and reversibly inhibits PKCbetaI and PKCbetaII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCbeta over other PKC isozymes (IC50values are 0.052, 0.25, 0.30,...
| Schlagworte: | LY 333531 hydrochloride, LY333531 HCl, Ruboxistaurin |
| Anwendung: | PKCbeta inhibitor |
| CAS | 169939-93-9 |
| MW: | 505.01 D |
ab 64,00 €
NPC-15437 (hydrochloride)
Artikelnummer: TGM-T37480-5mg
Description: NPC-15437 (hydrochloride) is a scleclive inhibitor of PKC interacling at the regulatory domain of the enzyme?. Target: Others. Smiles: Cl.Cl.CCCCCCCCCC CCC(=O)N1CCCCC1CNC(=O)[C@@H](N)CCCCN
| Anwendung: | PKC inhibitor |
| CAS | 141774-20-1 |
| MW: | 511.62 D |
ab 93,00 €
D-ERYTHRO-SPHINGOSINE
Artikelnummer: TGM-T5891-100mg
Description: D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator. Target: PKC, Phosphatase, Endogenous Metabolite. Smiles: CCCCCCCCCC CCC\C=C\[C@@H](O)[C@@H](N)CO. References: Khan W A , Dobrowsky R , El T S , et al....
| Schlagworte: | erythro-C18-Sphingosine, trans-4-Sphingenine, Erythrosphingosine |
| Anwendung: | PKC inhibitor |
| CAS | 123-78-4 |
| MW: | 299.49 D |
ab 39,00 €