Zu "K02216" wurden 160 Artikel gefunden!
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LY2606368
Artikelnummer: Cay21490-1
LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM. LY2606368, at 25 nM, also significantly induces apoptosis and...
| Schlagworte: | Prexasertib, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile |
| Anwendung: | CHK1 inhibitor |
| CAS | 1234015-52-1 |
| MW: | 365.4 D |
ab 34,00 €
CHK1 inhibitor
Artikelnummer: TGM-T10793-100mg
Description: CHK1 inhibitor (GDC-0575 analog) functions as a CHK1 inhibitor. Target: Chk. Smiles: N(C(=O)C1CC1)C=2C3=C(C(Br)=CC=C3NC2)N4C[C@H](N)CCC4
| Schlagworte: | GDC-0575 analog |
| Anwendung: | CHK1 inhibitor |
| CAS | 2097938-64-0 |
| MW: | 377.28 D |
ab 2.227,00 €
PD 407824
Artikelnummer: TGM-T16446-1mg
Description: PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively). Target: Chk, Wee1. Smiles: Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1....
| Schlagworte: | PD-407824 |
| Anwendung: | Chk1 / WEE1 inhibitor |
| CAS | 622864-54-4 |
| MW: | 328.32 D |
68,00 €
CCT244747
Artikelnummer: TGM-T14904-2mg
Description: CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM). Target: Chk. Smiles: COc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1-c1cnn(C)c1. References: Lainchbury M, et al. Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally...
| Anwendung: | Chk1 inhibitor |
| CAS | 1404095-34-6 |
| MW: | 408.46 D |
75,00 €
SB-218078
Artikelnummer: TGM-T16848-1mg
Description: SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50: 15 nM). Target: PKC, Chk. Smiles:...
| Anwendung: | Chk1 inhibitor |
| CAS | 135897-06-2 |
| MW: | 393.39 D |
345,00 €
SAR-020106
Artikelnummer: TGM-T21331-1mg
Description: SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme. Target: Chk. Smiles: C[C@H](CN(C)C)Oc1nc(Nc2cc3cccc(Cl)c3cn2)cnc1C#N. References: Walton M I , Eve P D , Hayes A , et al. The Preclinical Pharmacology and Therapeutic Activity...
| Anwendung: | Chk1 inhibitor |
| CAS | 1184843-57-9 |
| MW: | 382.85 D |
ab 44,00 €
Prexasertib
Artikelnummer: TGM-T4310-100mg
Description: Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. Target: Chk, Apoptosis. Smiles: COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1. References: King C, et al. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent...
| Schlagworte: | LY2606368 |
| Anwendung: | Targets serine/threonine-protein kinase CHEK1 [EC:2.7.11.1] (CHEK1) |
| CAS | 1234015-52-1 |
| MW: | 365.39 D |
ab 48,00 €
AZD7762 HCl
Artikelnummer: TGM-T6093L-50mg
Description: AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment. Target: Others. Smiles: Cl.NC(=O)Nc1cc(sc1C(=O)NC1CCCNC1)-c1cccc(F)c1. References: Cheng H, Merika E, Syrigos KN, Saif MW. Novel agents for the treatment of pancreatic adenocarcinoma....
| Schlagworte: | AZD7762 Hydrochloride |
| Anwendung: | CHK1/2 inhibitor |
| CAS | 1246094-78-9 |
| MW: | 398.88 D |
2.836,00 €
PF 477736
Artikelnummer: TGM-T6028-10mg
Description: PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes. Target: VEGFR, FGFR, Src, c-Fms, CDK, Chk, c-RET, FLT, Aurora Kinase. Smiles:...
| Schlagworte: | PF477736, PF-736,PF-00477736, PF 00477736, PF-477736 |
| Anwendung: | ATP-competitive Chk1 inhibitor |
| CAS | 952021-60-2 |
| MW: | 419.48 D |
ab 45,00 €
CCT245737
Artikelnummer: TGM-T7080-100mg
Description: CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM), CCT245737 shows much less activity against Chk2 (IC50: 2440 nM). Target: Chk. Smiles: FC(F)(F)c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1. References: Osborne JD, et al. Multiparameter Lead Optimization to Give an Oral...
| Schlagworte: | SRA737 |
| Anwendung: | Potent Chk1 inhibitor |
| CAS | 1489389-18-5 |
| MW: | 379.34 D |
ab 33,00 €
GDC-0575
Artikelnummer: TGM-T7300-100mg
Description: GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM). Target: Chk. Smiles: N[C@@H]1CCCN(C1)c1c(Br)cnc2[nH]cc(NC(=O)C3CC3)c12. References: Oo Z Y , Stevenson A J , Proctor M A , et al. Endogenous replication stress marks melanomas sensitive to CHK1 inhibitors in...
| Schlagworte: | ARRY-575, RG7741 |
| Anwendung: | Chk1 inhibitor |
| CAS | 1196541-47-5 |
| MW: | 378.27 D |
ab 51,00 €
Chk1 Protein, Mouse, Recombinant (His & GST)
Artikelnummer: TGM-TMPY-04433-50ug
Description: Chk1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 82.2 kDa and the accession number is O35280-1.
| Schlagworte: | checkpoint kinase 1, Chk1, C85740, rad27 |
| MW: | 82.2 kD |
487,00 €