Zu "K02211" wurden 77 Artikel gefunden!
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KB-0742
Artikelnummer: LKT-K040007.1
KB-0742 is a selective CDK9 inhibitor with potent anti-tumor activity in castration-resistant prostate cancer models. SMILES: CCC(CC)C1=NC2=CC=NN2C(=C1)NC3CCC(C3)N
| Schlagworte: | KB0742, NSC-834161, NSC834161, (1S,3S)-3-N-(5-pentan-3-ylpyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine |
| Anwendung: | CDK9 inhibitor. |
| CAS | 2170137-61-6 (base) |
| MW: | 287.41 D |
ab 283,00 €
KB-0742 dihydrochloride
Artikelnummer: LKT-K040009.1
KB-0742 dihydrochloride is a selective CDK9 inhibitor with potent anti-tumor activity in castration-resistant prostate cancer models.
| Schlagworte: | KB0742 dihydrochloride, NSC-834161 dihydrochloride, NSC834161 dihydrochloride,... |
| Anwendung: | CDK9 inhibitor. |
| CAS | 2416874-75-2 |
| MW: | 360.32 D |
ab 145,00 €
BAY-1251152
Artikelnummer: LKT-B030962.5
Inhibitor of PTEFb/CDK9.
| Schlagworte: | BAY 1251152, BAY1251152 |
| Anwendung: | CDK9 inhibitor |
| CAS | 1610358-56-9 |
| MW: | 404.44 D |
ab 123,00 €
RGB-286147
Artikelnummer: TGM-T28532-1mg
Description: RGB-286147 is a potent, selective, ATP-competitive Cdks inhibitor. Target: Others. Smiles: C(C)(C)C=1C2=C(N(N1)C3=C(Cl)C=CC=C3Cl)NC(CC4=CC=C(OCCO)C=C4)=NC2=O. References: Caligiuri M, Becker F, Murthi K, Kaplan F, Dedier S, Kaufmann C, Machl A, Zybarth G, Richard J, Bockovich N, Kluge A, Kley N. A...
| Anwendung: | Cdk inhibitor |
| CAS | 784211-09-2 |
| MW: | 473.35 D |
497,00 €
SNS-032
Artikelnummer: TGM-T6049-100mg
Description: SNS-032 (BMS-387032) is a selective inhibitor of CDK2 (IC50: 48 nM), exhibiting 10- and 20-fold selectivity over CDK1 and CDK4, respectively. It is also sensitive to CDK7 (IC50: 62 nM) and CDK9 (IC50: 4 nM), with no effect on CDK6. Target: CDK, Apoptosis, GSK-3. Smiles:...
| Schlagworte: | BMS-387032, SNS032 |
| Anwendung: | Cdk9 / Cdk2 / Cdk7 inhibitor |
| CAS | 345627-80-7 |
| MW: | 380.53 D |
ab 43,00 €
Riviciclib hydrochloride
Artikelnummer: TGM-T6924-10mg
Description: Riviciclib hydrochloride (P276-00) is a novel inhibitor of CDK1, CDK4, and CDK9, with IC50 values of 79 nM, 63 nM, and 20 nM, respectively, currently in Phase 2/3. Target: CDK, Apoptosis. Smiles: Cl.CN1CC[C@H]([C@@H]1CO)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl. References: Joshi KS, et al. Mol Cancer Ther,...
| Schlagworte: | P276-00 |
| Anwendung: | Cdk9 / Cdk4 / Cdk1 inhibitor |
| CAS | 920113-03-7 |
| MW: | 438.3 D |
ab 42,00 €
(S)-Enitociclib
Artikelnummer: TGM-T70388-10mg
Description: (S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that induces complete regression of MYC+ lymphomas by inhibiting RNA polymerase II-mediated transcription of anti-apoptotic and pro-survival proteins. Target: CDK. Smiles: COC1=C(C2=C(F)C=NC(NC3=CC(C[S@@](C)(=N)=O)=CC=N3)=C2)C=CC(F)=C1. References:...
| Schlagworte: | VIP152 |
| Anwendung: | Targets cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23] (CDK9) |
| CAS | 1610408-97-3 |
| MW: | 404.43 D |
ab 516,00 €
FIT-039
Artikelnummer: TGM-T8972-100mg
Description: FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 µM,CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 µM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses....
| Anwendung: | Cdk9 inhibitor |
| CAS | 1113044-49-7 |
| MW: | 315.41 D |
ab 31,00 €
LY2857785
Artikelnummer: TGM-TQ0060-100mg
Description: LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM). Target: CDK, Apoptosis. Smiles: CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(N[C@H]2CC[C@@H](CC2)NC2CCOCC2)n1. References: Yin T, et al. A novel CDK9 inhibitor shows potent antitumor efficacy in...
| Anwendung: | Cdk9 inhibitor |
| CAS | 1619903-54-6 |
| MW: | 448.6 D |
ab 48,00 €
LDC000067
Artikelnummer: TGM-T6563-100mg
Description: LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM. Target: CDK, Apoptosis. Smiles: COc1ccccc1-c1cc(Nc2cccc(CS(N)(=O)=O)c2)ncn1. References: Albert TK, et al. Br J Pharmacol. 2014, 171(1), 55-68.
| Schlagworte: | LDC067 |
| Anwendung: | Cdk9 inhibitor |
| CAS | 1073485-20-7 |
| MW: | 370.43 D |
ab 40,00 €
CDK9 inhibitor HH1
Artikelnummer: TGM-T118066-100mg
Description: CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 µM. Target: CDK. Smiles: CC(C)NC1=NC(N)=C(S1)C(=O)C1=CC=CC=C1. References: Schonbrunn E, et al. Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J...
| Schlagworte: | 8019-9719, 8019-9719 |
| Anwendung: | CDK9 inhibitor |
| CAS | 204188-41-0 |
| MW: | 261.34 D |
ab 48,00 €
(±)-Enitociclib
Artikelnummer: TGM-T13467-100mg
Description: (±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152, a highly selective inhibitor of PTEF/CDK9. Target: CDK. Smiles: COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=N)=O)ccn2)ncc1F. References: Luecking, et al. Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment...
| Schlagworte: | (±)-BAY-1251152 |
| Anwendung: | Cdk9 inhibitor racemic mixture |
| CAS | 1610358-53-6 |
| MW: | 404.43 D |
ab 60,00 €