Zu "K02206" wurden 157 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
SU 9516
Artikelnummer: Cay14796-1
SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1). It does not inhibit PKC, p38,...
| Schlagworte: | 1,3-dihydro-3Z-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one |
| Anwendung: | Pro-apoptotic Cdk2/cyclin A inhibitor |
| CAS | 377090-84-1 |
| MW: | 241.3 D |
ab 44,00 €
PF-07104091
Artikelnummer: LKT-P200091.1
PF-07104091 is a selective CDK2 inhibitor. SMILES: CC(C)NC(=O)OC1CCC(C1)C2=CC(=NN2)NC(=O)C3=CC(=NN3C)COC
| Schlagworte: | PF-07104091, PF 07104091, PF07104091, PF-7104091, PF 7104091, PF7104091,... |
| Anwendung: | CDK2 inhibitor |
| CAS | 2460249-19-6 |
| MW: | 404.47 D |
ab 229,00 €
PF-06873600
Artikelnummer: LKT-P200600.1
PF-06873600 is a selective inhibitor of CDK2/4/6 in multiple in vivo tumor models. SMILES: CC1(CCCC1N2C3=NC(=NC=C3C=C(C2=O)C(F)F)NC4CCN(CC4)S(=O)(=O)C)O
| Schlagworte: | PF06873600, Ebvaciclib,... |
| Anwendung: | CDK2/4/6 inhibitor |
| CAS | 2185857-97-8 |
| MW: | 471.52 D |
ab 222,00 €
PF-07104091
Artikelnummer: Cay41356-1
PF-07104091 is an inhibitor of cyclin-dependent kinase 2 (Cdk2, Ki = 1.16 nM). It is selective for Cdk2 over glycogen synthase kinase 3beta (GSK3beta, Ki = 537.81 nM). PF-07104091 decreases proliferation of TOV-21G and OVCAR-3 ovarian and HCT116 colorectal cancer cells (IC50s = 4.8, 0.59, and 0.88 µM, respectively)....
| Schlagworte: | Tagtociclib, carbamic acid... |
| Anwendung: | Cdk2 inhibitor |
| CAS | 2460249-19-6 |
| MW: | 404.5 D |
ab 75,00 €
K03861
Artikelnummer: Cay19921-10
K03861 is an inhibitor of cyclin-dependent kinase 2 (Cdk2). It binds to wild-type Cdk2, Cdk2C118L, Cdk2A144C, and Cdk2C118L/A144C (Kds = 50, 18.6, 15.4, and 9.7 nM, respectively). K03861 selectively inhibits the proliferation of IL-3-stimulated Ba/F3 cells expressing an FMS-related tyrosine kinase 3 bearing...
| Schlagworte: | AUZ454, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-urea |
| Anwendung: | Cdk2 inhibitor |
| CAS | 853299-07-7 |
| MW: | 501.5 D |
ab 95,00 €
PHA-793887
Artikelnummer: TGM-T2113-100mg
Description: PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors. Target: CDK, Apoptosis. Smiles: CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C. References: Brasca MG, et al. Bioorg Med Chem, 2010, 18(5), 1844-1853.
| Schlagworte: | PHA 793887, PHA793887 |
| Anwendung: | CDK2, CDK5, CDK7 inhibitor |
| CAS | 718630-59-2 |
| MW: | 361.48 D |
ab 45,00 €
Olomoucine
Artikelnummer: TGM-T21588-100mg
Description: Olomoucine is an ATP-competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3, and 25 µM, respectively. It regulates the cell cycle and exhibits anti-melanin tumor activities. Target: ERK, CDK. Smiles:...
| Anwendung: | Protein kinase inhibitor |
| CAS | 101622-51-9 |
| MW: | 298.34 D |
ab 60,00 €
Olomoucine II
Artikelnummer: TGM-T35696-1mg
Description: Olomoucine II is an inhibitor of cyclin-dependent kinases (CDKs, IC50s = 7.6, 0.1, 19.8, 0.45, and 0.06 µM for Cdk1, -2, -4, -7, and -9, respectively).1It is selective for CDKs over 10 additional kinases (IC50s = >100 µM for all) but does inhibit ERK2 (IC50= 32 µM) and the ATP-binding cassette...
| Anwendung: | CDK inhibitor |
| CAS | 500735-47-7 |
| MW: | 370.45 D |
108,00 €
NU6102
Artikelnummer: TGM-T28218-100mg
Description: NU6102 is a selective and potent ATP-competitive CDK2 inhibitor with antitumor activity against CDK1/cyclinB, CDK2/cyclinA3, CDK1/CDK2, CDK4, DYRK1A , PDK1, and ROCKII, and it can be used to study rectal cancer. Target: CDK. Smiles: NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1. References: Ian R...
| Schlagworte: | NU 6102, NU-6102 |
| Anwendung: | CDK1 and CDK2 Inhibitor |
| CAS | 444722-95-6 |
| MW: | 402.47 D |
ab 106,00 €
CVT-313
Artikelnummer: TGM-T3195-100mg
Description: CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor. Target: CDK. Smiles: COc1ccc(CNc2nc(nc3n(cnc23)C(C)C)N(CCO)CCO)cc1. References: Graub R, et al. Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing. Cell Cycle. 2008 Jun 15,7(12):1795-803.
| Schlagworte: | CVT313, Cdk2 Inhibitor III, CVT 313, NG26 |
| Anwendung: | Cdk2 inhibitor |
| CAS | 199986-75-9 |
| MW: | 400.47 D |
ab 38,00 €
Cdk2 Inhibitor II
Artikelnummer: TGM-T36933-100mg
Description: Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM. Target: CDK. Smiles: N(NC1=CC=C(S(N)(=O)=O)C=C1)=C2C=3C(NC2=O)=CC=C(Br)C3. References: S T Davis, et al. Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors. Science. 2001 Jan 5,291(5501):134-7.
| Schlagworte: | Cdk2 Inhibitor II, CDK2-IN-3 |
| Anwendung: | Cdk2 inhibitor |
| CAS | 222035-13-4 |
| MW: | 395.23 D |
ab 103,00 €
Purvalanol B
Artikelnummer: TGM-T7167-100mg
Description: Purvalanol B (NG 95) is a CDK inhibitor that targets Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B, with IC50 values of 6, 9, 6, and 6 nM, respectively. Target: CDK, Parasite. Smiles: CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c2ncn(C(C)C)c2n1. References: Bullard K M , Broccardo C , Keenan...
| Schlagworte: | NG 95 |
| Anwendung: | CDK inhibitor |
| CAS | 212844-54-7 |
| MW: | 432.9 D |
ab 33,00 €