Zu "K02206" wurden 163 Artikel gefunden!
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NEU
PF-07104091
Artikelnummer: Cay41356-1
PF-07104091 is an inhibitor of cyclin-dependent kinase 2 (Cdk2, Ki = 1.16 nM). It is selective for Cdk2 over glycogen synthase kinase 3beta (GSK3beta, Ki = 537.81 nM). PF-07104091 decreases proliferation of TOV-21G and OVCAR-3 ovarian and HCT116 colorectal cancer cells (IC50s = 4.8, 0.59, and 0.88 µM, respectively)....
| Schlagworte: | Tagtociclib, carbamic acid... |
| Anwendung: | Cdk2 inhibitor |
| CAS | 2460249-19-6 |
| MW: | 404.5 D |
ab 75,00 €
NEU
K03861
Artikelnummer: Cay19921-10
K03861 is an inhibitor of cyclin-dependent kinase 2 (Cdk2). It binds to wild-type Cdk2, Cdk2C118L, Cdk2A144C, and Cdk2C118L/A144C (Kds = 50, 18.6, 15.4, and 9.7 nM, respectively). K03861 selectively inhibits the proliferation of IL-3-stimulated Ba/F3 cells expressing an FMS-related tyrosine kinase 3 bearing...
| Schlagworte: | AUZ454, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-urea |
| Anwendung: | Cdk2 inhibitor |
| CAS | 853299-07-7 |
| MW: | 501.5 D |
ab 95,00 €
CK7
Artikelnummer: TGM-T9615-100mg
Description: CK7 (a Cdk2/9 inhibitor) is crucial in synthesizing Nek1 inhibitors [BSc5231] and [BSc5367]. Target: CDK. Smiles: Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1
| Anwendung: | Cdk2/Cdk9 inhibitor |
| CAS | 507487-89-0 |
| MW: | 328.35 D |
ab 73,00 €
PF07104091
Artikelnummer: TGM-T9712-100mg
Description: PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation. Target: CDK. Smiles: N(C(=O)C1=CC(COC)=NN1C)C2=CC(=NN2)[C@@H]3C[C@H](OC(NC(C)C)=O)CC3. References: Chen Y, Cai Q, Pan C, Liu W, Li L, Liu J, Gao M, Li X, Wang L, Rao Y, Yang H, Cheng G....
| Schlagworte: | PF-07104091 |
| Anwendung: | Targets cyclin-dependent kinase 2 [EC:2.7.11.22] (CDK2) |
| CAS | 2460249-19-6 |
| MW: | 404.46 D |
ab 364,00 €
Fadraciclib
Artikelnummer: TGM-TQ0053-100mg
Description: Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM). Target: CDK. Smiles: CC[C@H](Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1)[C@@H](C)O. References: Cocco E, et al. Dual CCNE1/PIK3CA targeting is synergistic in...
| Schlagworte: | CYC065 |
| Anwendung: | Cdk2 / Cdk9 inhibitor |
| CAS | 1070790-89-4 |
| MW: | 397.52 D |
ab 67,00 €
PHA-690509
Artikelnummer: TGM-T19657-100mg
Description: PHA-690509 is a cyclin-dependent kinase 2 inhibitor. It potentially for the treatment of cancer. Target: Others. Smiles: [C@H](C(NC=1SC(C(C)C)=CN1)=O)(C)C2=CC=C(NC(C)=O)C=C2
| Schlagworte: | PHA 690509 |
| Anwendung: | CDK inhibitor |
| CAS | 492445-28-0 |
| MW: | 331.43 D |
ab 1.491,00 €
SU9516
Artikelnummer: TGM-T6167-100mg
Description: SU9516 is a potent CDK2 inhibitor with an IC50 of 22 nM and also inhibits CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively. Target: PKC, Apoptosis, CDK, p38 MAPK, Autophagy. Smiles: C(=C\1/C=2C(NC1=O)=CC=C(OC)C2)\C3=CN=CN3. References: Lane ME, et al. Cancer Res. 2001, 61(16), 6170-6177.
| Anwendung: | CDK inhibitor |
| CAS | 377090-84-1 |
| MW: | 241.25 D |
ab 31,00 €
Milciclib
Artikelnummer: TGM-T6081-100mg
Description: Milciclib (PHA-848125) (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7. Phase 2. Target: CDK, Autophagy, Trk receptor. Smiles: CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21. References:...
| Schlagworte: | PHA-848125 |
| Anwendung: | Cdk inhibitor |
| CAS | 802539-81-7 |
| MW: | 460.57 D |
ab 81,00 €
(R)-CR8
Artikelnummer: TGM-T12617L-100mg
Description: (R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor. Target: CDK, Apoptosis. Smiles: CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccn2)c2ncn(C(C)C)c2n1. References: Kabadi SV, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after...
| Schlagworte: | CR8, (R)-Isomer, (R)-CR8 |
| Anwendung: | CDK inhibitor |
| CAS | 294646-77-8 |
| MW: | 431.53 D |
ab 60,00 €
NU6140
Artikelnummer: TGM-T16359-100mg
Description: NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 µM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity. Target: CDK, Aurora...
| Anwendung: | Cdk2 inhibitor |
| CAS | 444723-13-1 |
| MW: | 422.52 D |
ab 41,00 €
CDKI-73
Artikelnummer: TGM-T14919-100mg
Description: CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin. Target: Apoptosis, CDK. Smiles:...
| Anwendung: | Cdk9-cyclin T1 / Cdk1-cyclin B / Cdk2-cyclin A inhibitor |
| CAS | 1421693-22-2 |
| MW: | 394.45 D |
ab 143,00 €
PHA-793887
Artikelnummer: TGM-T2113-100mg
Description: PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors. Target: CDK, Apoptosis. Smiles: CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C. References: Brasca MG, et al. Bioorg Med Chem, 2010, 18(5), 1844-1853.
| Schlagworte: | PHA 793887, PHA793887 |
| Anwendung: | CDK2, CDK5, CDK7 inhibitor |
| CAS | 718630-59-2 |
| MW: | 361.48 D |
ab 45,00 €