Zu "K02089" wurden 89 Artikel gefunden!
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Anti-CDK4, clone GIC-3
Artikelnummer: NSJ-RQ5376
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The protein encoded by the CDK4 gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that...
| Schlagworte: | Anti-CDK4, Anti-PSK-J3, EC=2.7.11.22, Anti-Cyclin-dependent kinase 4, Anti-Cell division protein kinase 4, CDK4 Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
755,00 €
Anti-CDK4, clone HOB-3
Artikelnummer: NSJ-RQ5377
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The protein encoded by the CDK4 gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that...
| Schlagworte: | Anti-CDK4, Anti-PSK-J3, EC=2.7.11.22, Anti-Cyclin-dependent kinase 4, Anti-Cell division protein kinase 4, CDK4 Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
755,00 €
Human CDK4 (Cyclin Dependent Kinase 4) ELISA Kit
Artikelnummer: ELK-ELK1818.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CDK4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CDK4. Next,...
| Schlagworte: | CDK4, PSK-J3, EC=2.7.11.22, Cyclin-dependent kinase 4, Cell division protein kinase 4 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
CDK4 Assay Kit
Artikelnummer: BPS-79674
Cyclin-dependent kinase 4 (CDK4) assembles with the 'D' type of Cyclins, e.g. cyclins D1, D2, and D3, and play a pivotal role in the cell cycle entering the S phase. Dysregulation of the activity of CDK4 is related to many different cancers, indicating CDK4 inhibitors as promising anticancer treatments. In fact,...
| Schlagworte: | Cyclin-Dependent Kinase 4, Cell Division Kinase 4, CDK4, |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
810,00 €
LEE011 (succinate)
Artikelnummer: Cay36414-10
LEE011 is a cyclin-dependent kinase 4 (Cdk4) and Cdk6 inhibitor (IC50s = 0.53 and 2.3 nM, respectively). It is selective for Cdk4/6 over Cdk1, Cdk2, Cdk5, Cdk7, and Cdk9 (IC50s = >1,400, >2,500, >2,000, >2,000, and 190 nM, respectively). LEE011 reduces the proliferation of MCF-7 and T47D breast cancer cells (IC50s =...
| Schlagworte: | NVP-LEE011, Ribociclib, butanedioic acid, compd. with... |
| Anwendung: | Cdk4/6 inhibitor |
| CAS | 1374639-75-4 |
| MW: | 552.6 D |
ab 54,00 €
LY2835219 (methanesulfonate)
Artikelnummer: Cay17740-1
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when...
| Schlagworte: | Abemaciclib,... |
| Anwendung: | CDK4 / CDK6 inhibitor |
| CAS | 1231930-82-7 |
| MW: | 602.7 D |
ab 60,00 €
Arcyriaflavin A
Artikelnummer: Cay13516-1
Arcyriaflavin A is an inhibitor of cyclin-dependent kinase 4 (CDK4, IC50 = 140 nM) and calcium/calmodulin-dependent protein kinase II (CaMKII, IC50 = 25 nM). It is selective for CDK4 and CaMKII over protein kinase A (PKA) and PKC (IC50s = >2 and >100 µM, respectively). In vitro, arcyriaflavin A inhibits replication...
| Schlagworte: | 12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione |
| Anwendung: | CDK4 inhibitor |
| CAS | 118458-54-1 |
| MW: | 325.3 D |
ab 77,00 €
Cdk4 Inhibitor
Artikelnummer: Cay17648-1
Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 value of 0.8 µM. It is selective for cyclin D1/Cdk4, demonstrating 7-fold and 28-fold weaker activity against cyclin E/Cdk2 and cyclin B/Cdk1, respectively, and little...
| Schlagworte: | Cyclin-dependent kinase 4 Inhibitor, 2-bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione |
| Anwendung: | Cell-permeable Cdk4 inhibitor |
| CAS | 546102-60-7 |
| MW: | 404.2 D |
ab 92,00 €
LEE011
Artikelnummer: Cay17666-5
LEE011 is a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations. It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G1-S phase transition, arresting the cell cycle in the G1 phase, suppressing DNA synthesis, and inhibiting...
| Schlagworte: | Ribociclib, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide |
| Anwendung: | Cyclin D1/CDK4 & cyclin D3/CDK6 inhibitor |
| CAS | 1211441-98-3 |
| MW: | 434.5 D |
ab 54,00 €
PD 0332991 (hydrochloride)
Artikelnummer: Cay16273-1
PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma...
| Schlagworte: | Palbociclib, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one,... |
| Anwendung: | Cyclin-dependent kinase 4/6 (CDK4/6) inhibitor |
| CAS | 827022-32-2 |
| MW: | 484 D |
ab 50,00 €
Cdk4/6 Inhibitor IV
Artikelnummer: Cay17974-1
Cdk4/6 inhibitor IV is a cell-permeable triaminopyrimidine that reversibly blocks Cdk4/cyclin D1 and Cdk6/cyclin D1 activity with IC50 values of 1.5 and 5.6 µM, respectively. It demonstrates potent selectivity for Cdk4/6 over Cdk5/p35, v-abl, c-met, IGF-1R, insulin receptor, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin...
| Schlagworte: | CINK4, Cyclin-dependent kinase 4/6 Inhibitor IV,... |
| Anwendung: | Cdk4/cyclin D1 inhibitor, Cdk6/cyclin D1 inhibitor |
| CAS | 359886-84-3 |
| MW: | 456.6 D |
ab 58,00 €
LEE011
Artikelnummer: SYN-1213-M001
Solid. Soluble in DMSO. Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation...
| Schlagworte: | LEE-011, Ribociclib |
| Anwendung: | CDK4/CDK6 inhibitor |
| CAS | 1211441-98-3 |
| MW: | 434,5 D |
ab 66,00 €