Zu "K01648" wurden 67 Artikel gefunden!
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NDI-091143
Artikelnummer: TGM-T7424-100mg
Description: NDI-091143 is a potent, high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), indirectly disrupting citrate binding via an unexpected mechanism of inhibition. Target: ATP Citrate Lyase. Smiles: COC(=O)c1cc(Cl)c(O)c(c1)S(=O)(=O)Nc1cc(c(F)cc1F)-c1ccccc1....
| Anwendung: | ACLY inhibitor |
| CAS | 2375840-87-0 |
| MW: | 453.84 D |
ab 42,00 €
ATP citrate lyase/ACLY Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-02483-100ug
Description: ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP citrate lyase is responsible for catalyzing the conversion of citrate and CoA into...
| Schlagworte: | ATPCL, ACL, ATP citrate lyase, CLATP |
| MW: | 123 kD |
ab 386,00 €
SB 204990
Artikelnummer: TGM-T16861-100mg
Description: SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor. Target: ATP Citrate Lyase. Smiles: OC(=O)C[C@@]1(O)C[C@@H](CCCCCCc2ccc(Cl)cc2Cl)OC1=O. References: Shares BH, et al. Active mitochondria support osteogenic differentiation by stimulating beta-catenin acetylation. J Biol Chem....
| Anwendung: | ATP-citrate synthase (ACLY) inhibitor |
| CAS | 154566-12-8 |
| MW: | 389.27 D |
ab 41,00 €
Bempedoic acid
Artikelnummer: TGM-T3625-100mg
Description: Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic acid(ETC1002) is absorbed rapidly in the small intestine and enters the liver...
| Schlagworte: | ETC 1002, ETC-1002, ESP-55016, ETC1002 |
| Anwendung: | Targets ATP citrate (pro-S)-lyase [EC:2.3.3.8] (ACLY) |
| CAS | 738606-46-7 |
| MW: | 344.49 D |
ab 33,00 €
Anti-ACLY
Artikelnummer: CSB-PA000957.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-ACL, Anti-ACLY, Anti-ATP-citrate synthase, Anti-Citrate cleavage enzyme, Anti-ATP-citrate (pro-S-)-lyase, ACL... |
| Anwendung: | ELISA, WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat, monkey |
ab 126,00 €
Anti-ACLY
Artikelnummer: CSB-PA056430.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: ACLY. Antigen Species: Human
| Schlagworte: | Anti-ACL, Anti-ACLY, Anti-ATP-citrate synthase, Anti-Citrate cleavage enzyme, Anti-ATP-citrate (pro-S-)-lyase, ACL... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-ACLY
Artikelnummer: CSB-PA189814.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: ACLY. Antigen Species: Human
| Schlagworte: | Anti-ACL, Anti-ACLY, Anti-ATP-citrate synthase, Anti-Citrate cleavage enzyme, Anti-ATP-citrate (pro-S-)-lyase, ACL... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
MitoCheck(R) Citrate Synthase Activity Assay Kit
Artikelnummer: Cay701040-96
The condensation of the dicarboxylate oxaloacetate and acetyl CoA to the tricarboxylate citrate is catalyzed by citrate synthase. It is within this reaction that carbon molecules (as acetyl CoA) obtained from pyruvate oxidation are fed into the tricarboxylic acid (TCA or citric acid) cycle. As a mitochondrial...
| Schlagworte: | ACL, ACLY, EC=2.3.3.8, ATP-citrate synthase, Citrate cleavage enzyme, ATP-citrate (pro-S-)-lyase |
| Anwendung: | Citrate synthas activity determination |
595,00 €
ATP-citrate synthase (ACLY), partial, human, recombinant
Artikelnummer: CSB-EP001158HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 4-265aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: KAISEQTGKE LLYKFICTTS AIQNRFKYAR VTPDTDWARL LQDHPWLLSQ NLVVKPDQLI KRRGKLGLVG VNLTLDGVKS WLKPRLGQEA TVGKATGFLK NFLIEPFVPH SQAEEFYVCI YATREGDYVL...
| Schlagworte: | ACL, ACLY, ATP-citrate synthase, Citrate cleavage enzyme, ATP-citrate (pro-S-)-lyase, Recombinant Human ATP-citRate... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 45.5 kD |
ab 292,00 €
BMS 303141
Artikelnummer: Cay16239-5
ATP citrate lyase (ACL) catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg2+ as a cofactor. The ACL-dependent synthesis of acetyl-CoA is important for the de novo synthesis of fatty acids and cholesterol. Furthermore, as a key enzyme for linking glucose and lipid...
| Schlagworte: | 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide |
| Anwendung: | ATP citrate lyase (ACL) inhibitor |
| CAS | 943962-47-8 |
| MW: | 424.3 D |
ab 128,00 €
SB 204990
Artikelnummer: Cay15245-1
SB 204990 is a cell-permeable prodrug form of SB 201076, an inhibitor of ATP citrate lyase. SB 204990 inhibits fatty acid and cholesterol synthesis in HepG2 cells in a concentration-dependent manner. Oral administration of SB 204990 (25 mg/kg) reduces plasma levels of the lipoproteins VLDL, LDL, and HDL by 21, 40,...
| Schlagworte: | (3R,5S)-rel-5-[6-(2,4-dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid |
| Anwendung: | ATP-citrate synthase (ACLY) inhibitor |
| CAS | 154566-12-8 |
| MW: | 389.3 D |
ab 61,00 €
ACLY Assay Kit
Artikelnummer: BPS-79904
ATP citrate lyase (ACLY) is an important enzyme in fatty acid synthesis and cancer metabolism. The ACLY Assay Kit is designed to measure ACLY activity for screening and profiling applications using ADP-Glo(R) Kinase Assay as a detection reagent.
| Schlagworte: | ACL, ACLY, ATP-citrate synthase, Citrate cleavage enzyme, ATP-citrate (pro-S-)-lyase |
| Anwendung: | Enzyme kinetics, drug discovery, HTS |
| Spezies-Reaktivität: | human |
975,00 €