Zu "K01641" wurden 56 Artikel gefunden!
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Human HMGCS (Hydroxymethylglutaryl Coenzyme A Synthase)...
Artikelnummer: ELK-ELK2172.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human HMGCS. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human HMGCS. Next,...
| Schlagworte: | HMGCS, HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, Hydroxymethylglutaryl-CoA synthase, cytoplasmic |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Atorvastatin
Artikelnummer: LKT-A7658.10
Active hydroxy acid which works to restore cholesterol homeostasis. Inhibits HMG-CoA which leads to apoptosis of tumor cells.
| Schlagworte: | Atorvastatin Calcium Salt, Lipitor, Sortis: Torvast, Totalip, Xarator |
| Anwendung: | HMG-CoA inhibitor |
| CAS | 134523-03-8 |
| MW: | 1209,42 D |
ab 94,00 €
Fluvastatin (sodium salt hydrate)
Artikelnummer: Cay10010337-10
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
| Schlagworte: | 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid, sodium salt, hydrate |
| Anwendung: | Hydroxymethylglutaryl-coenzyme A reductase inhibitor |
| MW: | 410.5 D |
ab 35,00 €
Simvastatin (sodium salt)
Artikelnummer: Cay10010345-5
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
| Schlagworte: | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-nap... |
| Anwendung: | Inhibitor of HMG-CoA reductase |
| CAS | 101314-97-0 |
| MW: | 458.6 D |
ab 48,00 €
Pravastatin (sodium salt)
Artikelnummer: Cay10010343-25
Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the "statin" class of cholesterol-lowering drugs. Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin. It is a competitive inhibitor...
| Schlagworte: | 1S,2S,6S,7S,8R,8aR-hexahydro-betaR,deltaR,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid,... |
| Anwendung: | Potent HMG-CoA reductase inhibitor |
| CAS | 81131-70-6 |
| MW: | 446.5 D |
ab 35,00 €
Mevastatin
Artikelnummer: Cay10010340-50
Mevastatin is a competitive HMG-CoA reductase inhibitor (Ki = 0.1 µM). In vivo, mevastatin (50 mg/kg) inhibits cholesterogenesis in the liver and ileum of normolipidemic rats, as well as enhances suppression of cholesterogenesis in cholesterol-fed rats or rats administered cholestyramine. Mevastatin also suppresses...
| Schlagworte: | Compactin, CS 500, L-637,312, ML 236B, NSC 281245, Statin I,... |
| Anwendung: | HMG-CoA reductase inhibitor |
| CAS | 73573-88-3 |
| MW: | 390.5 D |
ab 43,00 €
Hymeglusin
Artikelnummer: Cay11899-1
Hymeglusin is a fungal beta-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 µM) by covalently modifying the active Cys129 residue of the enzyme. At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45%. Chiral studies indicate that the (2R,3R)-beta-lactone moiety of...
| Schlagworte: | Antibiotic 1233A, Antibiotic F 244, L 659,699,... |
| Anwendung: | HMG-CoA synthase inhibitor, Antibiotic |
| CAS | 29066-42-0 |
| MW: | 324.4 D |
ab 157,00 €
Lovastatin Hydroxy Acid (sodium salt)
Artikelnummer: Cay10010339-1
Lovastatin hydroxy acid is a potent and competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM). It is the more potent, open ring, hydroxy acid form of its prodrug, lovastatin (Cay-10010338).Formal Name:...
| Schlagworte: | 2-methyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthal... |
| Anwendung: | NF-kappaB activation inhibitor |
| CAS | 75225-50-2 |
| MW: | 444.5 D |
ab 50,00 €
-15 %
Rabattaktion
Anti-HMGCS1
Artikelnummer: A304-590A-T
Protein function: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. [The UniProt Consortium]
| Schlagworte: | Anti-HMGCS, Anti-HMGCS1, EC=2.3.3.10, Anti-HMG-CoA synthase, Anti-3-hydroxy-3-methylglutaryl coenzyme A synthase,... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
164,00 €
ab 139,40 €
Anti-HMGCS1
Artikelnummer: ARG55690.100
Protein function: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. [The UniProt Consortium]
| Schlagworte: | Anti-HMGCS, Anti-HMGCS1, EC=2.3.3.10, Anti-HMG-CoA synthase, Anti-3-hydroxy-3-methylglutaryl coenzyme A synthase,... |
| Anwendung: | IHC (paraffin), FC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
584,00 €
Human HMGCS1 ELISA Kit
Artikelnummer: G-HUFI01605.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
641,00 €
Anti-HMGCS1
Artikelnummer: NSJ-R36419-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: 3-hydroxy-3-methylglutaryl-CoA synthase 1 Protein function: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. [The UniProt...
| Schlagworte: | Anti-HMGCS, Anti-HMGCS1, EC=2.3.3.10, Anti-HMG-CoA synthase, Anti-3-hydroxy-3-methylglutaryl coenzyme A synthase,... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
755,00 €