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GSK 199 (hydrochloride)
Artikelnummer: Cay17489-5
GSK 199 is an inhibitor of peptidyl arginine deiminase 4 (PAD4, IC50 = 200 nM in the absence of calcium). It selectively inhibits the production of citrulline by PAD4 over PAD1, PAD2, and PAD3 in kinetic assays. GSK 199 (10 µM) prevents histone H3 citrullination and neutrophil extracellular trap (NET) formation...
| Schlagworte: | [(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone,... |
| Anwendung: | Reversible PADI4 inhibitor |
| CAS | 1549811-53-1 |
| MW: | 469 D |
ab 106,00 €
Cl-Amidine (hydrochloride)
Artikelnummer: Cay10599-1
Cl-Amidine is an irreversible inhibitor of protein arginine deiminases (PADs, IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively). It is cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 µM, respectively). Cl-amidine (50 mg/kg) reduces ex vivo extracellular neutrophil...
| Schlagworte: | N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide, monohydrochloride |
| Anwendung: | Peptidyl arginine deiminase (PAD) inhibitor |
| CAS | 1373232-26-8 |
| MW: | 347.2 D |
ab 66,00 €
YW3-56 (hydrochloride) (technical grade)
Artikelnummer: TGM-T36108-100mg
Description: YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 µM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 µM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in...
| Schlagworte: | YW3-56 (hydrochloride) (technical grade) |
| Anwendung: | PADI2 / PADI4 inhibitor |
| CAS | 2309756-20-3 |
| MW: | 530.49 D |
ab 2.375,00 €
CAY10727
Artikelnummer: TGM-T36393-1mg
Description: CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3, kinact/KI= 15,600 M-1min-1).1It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively). Target: Others. Smiles: ClC1=C(C2=CC(CN3C(=O)C(CCCNC(CCl)=N)NC3=O)=CC=C2)C=CC=C1. References: Jamali,...
| Anwendung: | PADI3 inhibitor |
| CAS | 1671088-84-8 |
| MW: | 433.33 D |
ab 289,00 €
Photoswitchable PAD Inhibitor (technical grade)
Artikelnummer: TGM-T35817-1mg
Description: Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 µM) and is less potent...
| Anwendung: | Photoswitchable protein arginine deiminase inhibitor |
| CAS | 2226393-62-8 |
| MW: | 487.98 D |
ab 289,00 €
Citrulline-specific Probe-Rhodamine
Artikelnummer: TGM-T36104-1mg
Description: Protein arginine deiminases (PADs) catalyze the posttranslational modification of arginine residues on proteins to form citrulline, which plays a large role in regulating gene expression. Abnormally high PAD activity has been observed in a host of human diseases. Citrulline-specific probe-rhodamine is a...
| Anwendung: | Fluorescent citrullination detection |
| CAS | 2309313-01-5 |
| MW: | 731.75 D |
ab 435,00 €
BB-Cl-Yne
Artikelnummer: TGM-T36632-1mg
Description: BB-Cl-Yne is a cell-permeable derivative of the protein arginine deiminase (PAD) inhibitor BB-Cl-amidine that contains an alkyne moiety for use in click chemistry reactions. BB-CL-Yne inhibits PAD1-4 with Kinact/KI values of 6,400, 3,600, 10,800, and 4,900 M-1min-1, respectively. It has been used for...
| Anwendung: | Cell-permeable BB-Cl-amidine derivative, click chemistry, PAD1-4 inhibitor |
| CAS | 2219324-71-5 |
| MW: | 483.99 D |
ab 269,00 €
F-Amidine TFA
Artikelnummer: TGM-T84479-10mg
Description: F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine...
| Anwendung: | Peptidyl arginine deiminase (PAD) inhibitor |
| CAS | 877617-46-4 |
| MW: | 408.4 D |
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GSK199
Artikelnummer: TGM-T8861-100mg
Description: GSK199 is a selective PAD4 inhibitor(IC50 of 200 nM in the absence of calcium). Target: PAD. Smiles: Cl.CCn1c(cc2cccnc12)-c1nc2cc(cc(OC)c2n1C)C(=O)N1CCC[C@@H](N)C1. References: Willis V C , Banda N K , Cordova K N , et al. Protein arginine deiminase 4 inhibition is sufficient for the amelioration of...
| Anwendung: | Reversible PADI4 inhibitor |
| CAS | 1549811-53-1 |
| MW: | 468.98 D |
ab 96,00 €
PADI2 Protein, Human, Recombinant (His & Myc)
Artikelnummer: TGM-TMPH-01965-100ug
Description: PADI2 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
| Schlagworte: | PAD-H19, Peptidylarginine deiminase II, Protein-arginine deiminase type-2, PADI2, Protein-arginine deiminase type II |
| MW: | 80.6 kD |
ab 360,00 €
PADI2 Protein, Human, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-01966-100ug
Description: PADI2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
| Schlagworte: | Peptidylarginine deiminase II, Protein-arginine deiminase type-2, PADI2, Protein-arginine deiminase type II, PAD-H19 |
| MW: | 91.6 kD |
ab 193,00 €
PADI3 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01967-100ug
Description: PADI3 Protein, Human, Recombinant (His) is expressed in Yeast.
| Schlagworte: | Protein-arginine deiminase type III, PADI3, Peptidylarginine deiminase III, Protein-arginine deiminase type-3 |
| MW: | 76.7 kD |
ab 333,00 €