Zu "K01425" wurden 71 Artikel gefunden!
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GLS1 Inhibitor
Artikelnummer: TGM-T37222-10mg
Description: GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1, IC50= 0.021 µM).1It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cellsin vitro(GI50= 0.011 µM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and...
| Anwendung: | GLS1 (K-glutaminase) inhibitor |
| CAS | 1832646-52-2 |
| MW: | 411.48 D |
ab 77,00 €
Telaglenastat hydrochloride
Artikelnummer: TGM-T39309-5mg
Description: Telaglenastat (CB-839) hydrochloride is a first-in-class, reversible, and orally active inhibitor of glutaminase 1 (GLS1), selectively inhibiting the splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C), as opposed to GLS2. Telaglenastat hydrochloride has an IC50 of 23 nM for endogenous...
| Schlagworte: | CB-839 hydrochloride |
| Anwendung: | Targets glutaminase [EC:3.5.1.2] (glsA, GLS) |
| CAS | 1874231-60-3 |
| MW: | 608.04 D |
951,00 €
Glutaminase C-IN-1
Artikelnummer: TGM-T3964-100mg
Description: Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C (GLS1). Target: Glutaminase. Smiles: CN(C)c1ccc(cc1Br)C1Nc2ccc3ccccc3c2C2=C1C(=O)CC(C)(C)C2. References: Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in...
| Schlagworte: | Compound 968, Glutaminase Inhibitor Compound 968 |
| Anwendung: | Glutaminase inhibitor |
| CAS | 311795-38-7 |
| MW: | 475.42 D |
ab 35,00 €
GLS1 Inhibitor-4
Artikelnummer: TGM-T72679-100mg
Description: GLS1 Inhibitor-4 (compound 41e) is a potent GLS1 inhibitor with an IC50 of 11.86 nM, exhibiting antiproliferative effects, substantial metabolic stability, and strong GLS1 binding affinity. It disrupts glutamine metabolism, induces ROS production, triggers apoptosis, and demonstrates notable antitumor...
| Anwendung: | GLS1 (K-glutaminase) inhibitor |
| CAS | 2768599-97-7 |
| MW: | 668.72 D |
ab 1.491,00 €
GLS1 Inhibitor-3
Artikelnummer: TGM-T64211-100mg
Description: GLS1 Inhibitor-3 (compound C147) is a potent GLS1 inhibitor (IC50: 27.98 nM) with anti-proliferative effects. Target: Others. Smiles: C(N1C=C(CCC(NC2=CC=C(CCCCC=3SC(NC(CC4=CC=CC=N4)=O)=NN3)N=N2)=O)N=N1)C5=CC=C(C)C=C5
| Anwendung: | GLS1 (K-glutaminase) inhibitor |
| CAS | 2435781-94-3 |
| MW: | 596.71 D |
ab 1.491,00 €
BPTES
Artikelnummer: TGM-T6791-100mg
Description: BPTES(IC50 of 0.16 µM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor. Target: Glutaminase, transporter. Smiles: O=C(Cc1ccccc1)Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1. References: Newcomb R. 2002. U.S. Pat. 6,451,828 B1.
| Anwendung: | Selective, allosteric non-competitive glutaminase 1 (GLS1) inhibitor |
| CAS | 314045-39-1 |
| MW: | 524.68 D |
ab 32,00 €
Telaglenastat
Artikelnummer: TGM-T6797-100mg
Description: Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC. Target: Autophagy, transporter, Glutaminase. Smiles: FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)c1. References: Gross MI, et al....
| Schlagworte: | CB 839, CB839, CB-839 |
| Anwendung: | Targets glutaminase [EC:3.5.1.2] (glsA, GLS) |
| CAS | 1439399-58-2 |
| MW: | 571.57 D |
ab 33,00 €
Glutaminase 1 (glsA1), Escherichia coli, recombinant
Artikelnummer: CSB-EP302868ENV.1
Organism: Escherichia coli (strain K12). Source: E.coli. Expression Region: 1-310aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-GST-tagged. Target Protein Sequence: MLDANKLQQA VDQAYTQFHS LNGGQNADYI PFLANVPGQL AAVAIVTCDG NVYSAGDSDY RFALESISKV CTLALALEDV GPQAVQDKIG ADPTGLPFNS VIALELHGGK PLSPLVNAGA...
| Schlagworte: | ybaS, b0485, Glutaminase 1, Recombinant Escherichia coli Glutaminase 1 (glsA1) |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | E.coli |
| MW: | 62.9 kD |
ab 354,00 €
Glutaminase liver isoform, mitochondrial (GLS2), human,...
Artikelnummer: CSB-EP887058HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 15-602aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: GSHCGRGGWG HPSRSPLLGG GVRHHLSEAA AQGRETPHSH QPQHQDHDSS ESGMLSRLGD LLFYTIAEGQ ERIPIHKFTT ALKATGLQTS DPRLRDCMSE MHRVVQESSS...
| Schlagworte: | GA, GLS, GLS2, L-glutaminase, L-glutamine amidohydrolase, Glutaminase liver isoform, mitochondrial, Recombinant Human... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 80.7 kD |
ab 283,00 €
Anti-GLS
Artikelnummer: CSB-PA177709.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: GLS. Antigen Species: Human
| Schlagworte: | Anti-GLS, Anti-GLS1, AAD20 antibody, DKFZp686O15119 antibody, FLJ10358 antibody, GAC antibody, GAM antibody, GLS antibody,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
Anti-GLS
Artikelnummer: CSB-PA969762.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: GLS. Antigen Species: Human
| Schlagworte: | Anti-GLS, Anti-GLS1, AAD20 antibody, DKFZp686O15119 antibody, FLJ10358 antibody, GAC antibody, GAM antibody, GLS antibody,... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
CB-839
Artikelnummer: Cay22038-5
CB-839 is an orally bioavailable noncompetitive inhibitor of the glutaminase 1 (GLS1) splice variants, kidney-type (KGA) and glutaminase C (GAC), which convert glutamine into glutamate. CB-839 inhibits human recombinant GAC with IC50 values of less than 50 nM, varying based on the length of preincubation. It...
| Schlagworte: | GLS1 Inhibitor III,... |
| Anwendung: | Glutaminase inhibitor |
| CAS | 1439399-58-2 |
| MW: | 571.6 D |
ab 77,00 €