Zu "K01371" wurden 107 Artikel gefunden!
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E-64
Artikelnummer: TGM-T6037-25mg
Description: E-64 (Proteinase inhibitor E 64) is an irreversible and specific inhibitor of cysteine proteases, exhibiting an IC50 of 9 nM for papain. Target: Antibacterial, Cysteine Protease, Autophagy. Smiles: CC(C)CC(NC(=O)C1OC1C(O)=O)C(=O)NCCCCN=C(N)N. References: Matsumoto K, et al. Biopolymers. 1999, 51(1),...
| Schlagworte: | E64, Proteinase inhibitor E 64, E 64 |
| Anwendung: | Cysteine protease inhibitor |
| CAS | 66701-25-5 |
| MW: | 357.41 D |
ab 31,00 €
Relacatib
Artikelnummer: TGM-T40463-5mg
Description: Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V, exhibiting high affinity with Ki values of 41 pM, 68 pM, and 53 pM, respectively. It effectively inhibits endogenous cathepsin K in situ in human osteoclasts and human osteoclast-mediated bone...
| Schlagworte: | SB-462795 |
| Anwendung: | Targets cathepsin K [EC:3.4.22.38] (CTSK) |
| CAS | 362505-84-8 |
| MW: | 540.64 D |
1.971,00 €
Odanacatib
Artikelnummer: TGM-T6035-100mg
Description: Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Target: Cysteine Protease. Smiles: CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NC1(CC1)C#N. References: Gauthier JY, et al. Bioorg Med Chem Lett. 2008, 18(3), 923-928.
| Schlagworte: | MK-0822 |
| Anwendung: | Targets cathepsin K [EC:3.4.22.38] (CTSK) |
| CAS | 603139-19-1 |
| MW: | 525.56 D |
ab 45,00 €
Cathepsin K inhibitor 3
Artikelnummer: TGM-T72296-100mg
Description: Cathepsin K Inhibitor 3, exhibiting an IC50 value of 0.5 nM, is a highly selective inhibitor of cathepsin K, featuring a favorable pharmacokinetic profile. It holds potential for use in studies of osteoarthritis (OA). Target: Others. Smiles:...
| Anwendung: | Cathepsin K inhibitor |
| CAS | 1694638-70-4 |
| MW: | 562.65 D |
ab 2.121,00 €
2-Cyanopyrimidine
Artikelnummer: TGM-T7451-1g
Description: 2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM). Target: Cysteine Protease. Smiles: N#CC1=NC=CC=N1. References: Rankovic Z , Cai J , Kerr J , et al. Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: Improving selectivity over hERG[J]. Bioorganic...
| Schlagworte: | 2-cyano-Pyrimidine |
| Anwendung: | Cathepsin K inhibitor |
| CAS | 14080-23-0 |
| MW: | 105.1 D |
ab 30,00 €
Cathepsin K Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01061-100ug
Description: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone...
| Schlagworte: | CTSO, Cathepsin K, Cathepsin O, CTSK, CTSO2, Cathepsin X, Cathepsin O2 |
| MW: | 27.5 kD |
ab 198,00 €
Cathepsin K Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPH-02565-100ug
Description: Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the...
| Schlagworte: | Cathepsin O2, CTSO2, Cathepsin X, CTSO, Cathepsin K, CTSK, Cathepsin O |
| MW: | 27.4 kD |
ab 281,00 €
Cathepsin K Protein, Rat, Recombinant (His)
Artikelnummer: TGM-TMPH-03262-100ug
Description: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone...
| Schlagworte: | Cathepsin K, CTSK, CTSO, CTSO2, Cathepsin O2, Cathepsin O, Cathepsin X |
| MW: | 27.5 kD |
ab 281,00 €
Balicatib
Artikelnummer: TGM-T1850-100mg
Description: Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis. Target: Cysteine Protease. Smiles: CCCN1CCN(CC1)c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N. References: Jerome C, et al. Osteoporos Int. 2012 Jan,23(1):339-49.
| Schlagworte: | AAE581 |
| Anwendung: | Cathepsin K inhibitor |
| CAS | 354813-19-7 |
| MW: | 411.54 D |
ab 37,00 €
Cathepsin K inhibitor 2
Artikelnummer: TGM-T64159-100mg
Description: Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K, a cysteine protease expressed under the control of the CTSK gene, which is closely related to osteoporosis and hydrolyses collagen. Cathepsin K inhibitor 2 has shown potential in osteoarthritis. Target: Others. Smiles:...
| Anwendung: | Cathepsin K inhibitor |
| CAS | 2672478-52-1 |
| MW: | 587.61 D |
ab 2.142,00 €
Calpeptin
Artikelnummer: TGM-T6432-100mg
Description: Calpeptin is a potent, cell-permeable calpain inhibitor. Target: Proteasome, Apoptosis, Cysteine Protease. Smiles: CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O. References: Tsujinaka T, et al. Biochem Biophys Res Commun. 1988, 153(3), 1201-1208.
| Anwendung: | Calpain inhibitor, cathepsin K inhibitor |
| CAS | 117591-20-5 |
| MW: | 362.46 D |
ab 31,00 €
Cathepsin K (CTSK), dog, recombinant
Artikelnummer: CSB-EP006192DO.1
Organism: Canis lupus familiaris (Dog) (Canis familiaris). Source: E.coli. Expression Region: 116-330aa. Protein Length: Full Length of Mature Protein. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: APDSVDYRKK GYVTPVKNQG QCGSCWAFSS VGALEGQLKK KTGKLLNLSP QNLVDCVSEN DGCGGGYMTN AFQYVQKNRG IDSEDAYPYV...
| Schlagworte: | CTSK, Cathepsin K, EC=3.4.22.38, Recombinant Dog Cathepsin K (CTSK) |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | dog |
| MW: | 39.5 kD |
ab 364,00 €