Zu "K01278" wurden 262 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
DPP (IV) Inhibitor Screening Assay Kit
Artikelnummer: Cay700210-96
DPP (IV) inhibitors have emerged as a new class of oral antidiabetic agents. These inhibitors promote glucose homeostasis by inhibiting degradation of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) by DPP (IV). GLP-1 extends the action of insulin while suppressing the release...
| Schlagworte: | Dipeptidyl peptidase IV |
| Anwendung: | DPP (IV) inhibitor screening |
| Spezies-Reaktivität: | human |
467,00 €
NEU
DBPR108
Artikelnummer: Cay41117-10
DBPR108 is an inhibitor of dipeptidyl peptidase 4 (DPP-4, IC50 = 0.015 µM). It is selective for DPP-4 over DPP-8 and DPP-9 (IC50s = >50 µM for both). DBPR108 (10 mg/kg) increases plasma levels of glucagon-like peptide 1 (GLP-1) and insulin in rats. It reduces blood glucose levels in an oral glucose tolerance test in...
| Schlagworte: | Prusogliptin, 1-[2S-[[1,1-dimethyl-3-oxo-3-(1-pyrrolidinyl)propyl]amino]acetyl]-4S-fluoro-2-pyrrolidinecarbonitrile |
| Anwendung: | DPP-4 inhibitor |
| CAS | 1186426-66-3 |
| MW: | 324.4 D |
ab 136,00 €
Vildagliptin
Artikelnummer: TGM-T1502-100mg
Description: Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolite is excreted mainly via the urine. Target: Ferroptosis, Proteasome, Apoptosis,...
| Schlagworte: | LAF237, NVP-LAF 237 |
| Anwendung: | Targets dipeptidyl-peptidase 4 [EC:3.4.14.5] (DPP4, CD26) |
| CAS | 274901-16-5 |
| MW: | 303.4 D |
ab 31,00 €
Vildagliptin carboxylic acid metabolite (trifluoroacetate...
Artikelnummer: TGM-T35815-1mg
Description: Vildagliptin carboxylic acid metabolite is the major metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor vildagliptin in humans. Vildagliptin carboxylic acid metabolite has an IC50 value of 477 µM for DPP-4 in human Caco-2 cells. It is formed from hydrolysis of the cyano group on vildagliptin....
| Anwendung: | Major vildagliptin metabolite |
| CAS | 565453-41-0 |
| MW: | 436.428 D |
ab 140,00 €
Camegliptin
Artikelnummer: TGM-T26941-25mg
Description: Cameglipti, a dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type 2 diabetes. Target: Others. Smiles: O(C)C=1C=C2[C@]3(N(C[C@@H]([C@@H](N)C3)N4C[C@@H](CF)CC4=O)CCC2=CC1OC)[H]. References: Kuhlmann O, Carlile D, Noe J, Bentley D. Interaction potential of Carmegliptin...
| Schlagworte: | R-1579, RG-1579, RO-4876904, RG1579, RO-4876904-001, R1579 |
| Anwendung: | Targets dipeptidyl-peptidase 4 [EC:3.4.14.5] (DPP4, CD26) |
| CAS | 813452-18-5 |
| MW: | 377.45 D |
ab 2.375,00 €
Gly-Pro-pNA hydrochloride
Artikelnummer: TGM-T36583-100mg
Description: Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase IV and dipeptidyl peptidase IX. Target: Proteasome. Smiles: Cl.NCC(=O)N1CCCC1C(=O)Nc1ccc(cc1)[N+]([O-])=O. References: Rai C, et al. Whey...
| Schlagworte: | Gly-Pro p-nitroanilide hydrochloride |
| Anwendung: | Chromogenic DPP4 substrate |
| CAS | 103213-34-9 |
| MW: | 328.75 D |
ab 34,00 €
P32/98
Artikelnummer: TGM-T38771-5mg
Description: P32/98 is a potent inhibitor of dipeptidyl peptidase IV . P32/98 improves glucose tolerance, insulin sensitivity and beta-cell responsiveness in preclinical studies using the fatty Zucker rat, an animal model for IGT (impaired glucose tolerance). Target: Others. Smiles: CC[C@H](C)[C@H](N)C(=O)N1CCSC1....
| Schlagworte: | P32/98 |
| Anwendung: | DPPIV inhibitor |
| CAS | 136259-20-6 |
| MW: | 202.32 D |
951,00 €
Teneligliptin
Artikelnummer: TGM-T37522-10mg
Description: Teneligliptin (MP-513) is a potent prolylthiazolidine-based DPP-4 inhibitor that competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM. Target: Others. Smiles: Cc1cc(N2CCN(CC2)[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)n(n1)-c1ccccc1....
| Anwendung: | Targets dipeptidyl-peptidase 4 [EC:3.4.14.5] (DPP4, CD26) |
| CAS | 760937-92-6 |
| MW: | 426.58 D |
ab 31,00 €
Saxagliptin hydrochloride
Artikelnummer: TGM-T6203L-5mg
Description: Saxagliptin is a new oral hypoglycemic of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Saxagliptin is a competitive DPP4 inhibitor that slows the inactivation of the incretin hormones and reducing fasting and postprandial glucose concentrations in a glucose-dependent manner in...
| Schlagworte: | Saxagliptin HCl, BMS-477118, Saxagliptin, BMS477118, BMS 477118 |
| Anwendung: | Targets dipeptidyl-peptidase 4 [EC:3.4.14.5] (DPP4, CD26) |
| CAS | 709031-78-7 |
| MW: | 351.87 D |
951,00 €
Carmegliptin dihydrochloride
Artikelnummer: TGM-T68652-100mg
Description: Carmegliptin dihydrochloride is the salt form of Camegliptin (free base), also known as RG-1579 and RO4876904, a dipeptidyl peptidase IV (DPP-4) inhibitor potentially for the treatment of type 2 diabetes. Target: Others. Smiles: Cl.Cl.[H][C@@]12C[C@H](N)[C@H](CN1CCc1cc(OC)c(OC)cc21)N1C[C@@H](CF)CC1=O
| Anwendung: | Targets dipeptidyl-peptidase 4 [EC:3.4.14.5] (DPP4, CD26) |
| CAS | 813452-14-1 |
| MW: | 450.38 D |
ab 2.375,00 €
Anagliptin
Artikelnummer: TGM-T7133-100mg
Description: Anagliptin (SK-0403) is a potent inhibitor of DPP-4 (IC50 of 3.8 nM) used in the treatment of type 2 diabetes mellitus. Target: DPP-4, Proteasome. Smiles: Cc1cc2ncc(cn2n1)C(=O)NCC(C)(C)NCC(=O)N1CCC[C@H]1C#N. References: Ervinna N, et al. Anagliptin, a DPP-4 inhibitor, suppresses proliferation of...
| Schlagworte: | SK-0403 |
| Anwendung: | Targets dipeptidyl-peptidase 4 [EC:3.4.14.5] (DPP4, CD26) |
| CAS | 739366-20-2 |
| MW: | 383.45 D |
ab 39,00 €
Gemigliptin
Artikelnummer: TGM-T7369-100mg
Description: Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.). Target: DPP-4, Proteasome. Smiles: N[C@H](CN1CC(F)(F)CCC1=O)CC(=O)N1CCc2c(C1)nc(nc2C(F)(F)F)C(F)(F)F. References: Choi S Y , Ryu H M , Oh E J , et al. Dipeptidyl peptidase-4 inhibitor gemigliptin protects...
| Schlagworte: | LC15-0444 |
| Anwendung: | Targets dipeptidyl-peptidase 4 [EC:3.4.14.5] (DPP4, CD26) |
| CAS | 911637-19-9 |
| MW: | 489.36 D |
ab 34,00 €