Zu "K01201" wurden 52 Artikel gefunden!
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Gcase activator 1
Artikelnummer: TGM-T4280-100mg
Description: Gcase activator 1 (LTI-291) is a glucocerebrosidase (Gcase) activator. Target: Glucosidase. Smiles: CCCCCO[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2c(C)cc(C)nc12. References: Renato T. Skerlj, et al. Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds. WO...
| Schlagworte: | LTI291, LTI-291, LTI 291 |
| Anwendung: | GCase allosteric activator |
| CAS | 1919820-28-2 |
| MW: | 358.48 D |
ab 41,00 €
Glucosylsphingosine
Artikelnummer: TGM-T78493-1mg
Description: Glucosylsphingosine (lyso-Gb1), a deacylated glucosylceramide derivative metabolized by glucocerebrosidase, serves as a promising, reliable, and specific biomarker for Gaucher disease monitoring [1]. Target: Others. Smiles: CCCCCCCCCC CCC\C=C\[C@@H](O)[C@@H](N)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
| Schlagworte: | Glucopsychosine, Lyso-Gb1 |
| Anwendung: | Cytotoxic compound |
| CAS | 52050-17-6 |
| MW: | 461.63 D |
ab 274,00 €
ML198
Artikelnummer: TGM-T8986-100mg
Description: ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease. Target: Glucokinase. Smiles: Cc1cc(C)n2ncc(C(=O)Nc3ccc(cc3)C#C)c2n1. References:...
| Anwendung: | Glucocerebrosidase chemical chaperone |
| CAS | 1380716-06-2 |
| MW: | 290.32 D |
ab 40,00 €
NCGC 607
Artikelnummer: TGM-T8989-100mg
Description: NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase). Target: Others. Smiles: CN(C(=O)CNC(=O)c1ccccc1OCC(=O)Nc1ccc(I)cc1)c1ccccc1. References: Aflaki E , Borger D K , Moaven N , et al. A New Glucocerebrosidase Chaperone Reduces alpha-Synuclein and Glycolipid Levels in iPSC-Derived...
| Schlagworte: | NCGC607 |
| Anwendung: | Glucocerebrosidase activator |
| CAS | 1462267-07-7 |
| MW: | 543.35 D |
ab 42,00 €
GBA Protein, Mouse, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-02771-100ug
Description: GBA Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli.
| Schlagworte: | Acid beta-glucosidase, Cholesterol glucosyltransferase, Beta-glucocerebrosidase, Lysosomal glycosylceramidase, Lysosomal... |
| MW: | 71.5 kD |
ab 278,00 €
GBA Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPH-02772-100ug
Description: GBA Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 57.5 kDa and the accession number is P17439.
| Schlagworte: | Cholesteryl-beta-glucosidase, Lysosomal galactosylceramidase, Acid beta-glucosidase, D-glucosyl-N-acylsphingosine... |
| MW: | 57.5 kD |
ab 333,00 €
GBA Protein, Human, Recombinant (His & Myc & SUMO)
Artikelnummer: TGM-TMPH-01623-100ug
Description: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in...
| Schlagworte: | Cholesteryl-beta-glucosidase, Glucosylceramidase beta 1, Imiglucerase, Beta-glucosylceramidase 1, Lysosomal... |
| MW: | 75.6 kD |
ab 193,00 €
GBA Protein, Human, Recombinant
Artikelnummer: TGM-TMPH-01624-100ug
Description: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in...
| Schlagworte: | Cholesterol glucosyltransferase, D-glucosyl-N-acylsphingosine glucohydrolase, Cholesteryl-beta-glucosidase, Lysosomal... |
| MW: | 55.6 kD |
ab 354,00 €
GBA/glucocerebrosidase Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-05099-50ug
Description: Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine...
| Schlagworte: | glucosidase, beta, acid, GBA1, GCB, glucosidase, beta, acid, GLUC |
| MW: | 57 kD |
686,00 €
Conduritol B epoxide
Artikelnummer: TGM-TQ0300-100mg
Description: Conduritol B epoxide is an irreversible inhibitor of beta-glucosidase (GCase). Target: Glucosidase. Smiles: O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O. References: Liou B, et al. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet....
| Anwendung: | Irreversible glucocerebrosidase inhibitor |
| CAS | 6090-95-5 |
| MW: | 162.14 D |
ab 41,00 €
Afegostat D-Tartrate
Artikelnummer: TGM-T19182-10mg
Description: Afegostat D-Tartrate is a pharmacological chaperone that binds specifically and reversibly with high affinity to acid-beta-glucosidase (GCase) in the endoplasmic reticulum. Target: Others. Smiles: [C@H]([C@@H](C(O)=O)O)(C(O)=O)O.C(O)[C@@H]1[C@@H](O)[C@H](O)CNC1. References: Richter F, et al. A GCase...
| Schlagworte: | D-Isofagomine D-Tartrate, Isofagomine D-Tartrate |
| Anwendung: | Competitive glucosylceramidase (GBA) inhibitor |
| CAS | 957230-65-8 |
| MW: | 297.26 D |
ab 263,00 €
Glucosylceramidase (GBA), human, recombinant
Artikelnummer: CSB-YP009289HU.1
Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 40-536aa. Protein Length: Full Length of Mature Protein. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: ARPCIPKSFG YSSVVCVCNA TYCDSFDPPT FPALGTFSRY ESTRSGRRME LSMGPIQANH TGTGLLLTLQ PEQKFQKVKG FGGAMTDAAA LNILALSPPA QNLLLKSYFS EEGIGYNIIR...
| Schlagworte: | GC, SGTase, Beta-GC, Alglucerase, Imiglucerase, Lysosomal acid GCase, Acid beta-glucosidase, Beta-glucocerebrosidase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | Yeast |
| Ursprungsart: | human |
| MW: | 57.1 kD |
ab 336,00 €