Zu "K00922" wurden 339 Artikel gefunden!
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LY294002
Artikelnummer: Cay70920-5
LY294002 is a multi-kinase inhibitor. It inhibits casein kinase 2 (CK2, IC50 = 0.098 µM), the PI3K subunits p110alpha, p110beta, p110delta, and p110gamma (IC50s = 0.497, 0.554, 0.331, and 3.8 µM, respectively), and DNA protein kinase (DNA-PK, IC50 = 6 µM), among other kinases, as well as CK1, GSK3alpha, and GSK3beta...
| Schlagworte: | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |
| Anwendung: | PI3K inhibitor |
| CAS | 154447-36-6 |
| MW: | 307.3 D |
ab 36,00 €
PI-3 Kinase Lipid Substrate
Artikelnummer: BPS-40560
PI/PS (4:1, w/w) unilamellar vesicle, prepared with L-alpha-phosphatidylinositol (Liver, Bovine) (sodium salt) and L-alpha-phosphatidylserine (Brain, Porcine) (sodium salt). Lipid monolayer was formed by sonication. Application: Useful as a substrate for PI-3 kinase activity assays and other lipid kinases....
| Anwendung: | PI-3 kinase substrate |
581,00 €
Wortmannin
Artikelnummer: Cay10010591-1
By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse cellular functions, including cell growth, differentiation, survival, and motility. Wortmannin is a potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM). However, the class II PI3Ks from...
| Schlagworte: | KY 12420,... |
| Anwendung: | PI3K inhibitor |
| CAS | 19545-26-7 |
| MW: | 428.4 D |
ab 61,00 €
3-Methyladenine
Artikelnummer: Cay13242-25
Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms....
| Schlagworte: | 3-MA, NSC 66389, 3-methyl-3H-purin-6-amine |
| Anwendung: | PI3K inhibitor |
| CAS | 5142-23-4 |
| MW: | 149.2 D |
ab 45,00 €
Anti-PIK3CA
Artikelnummer: ABS-KC-3277.100
Protein function: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396, PubMed:23936502, PubMed:28676499). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to...
| Schlagworte: | Anti-Phosphatidylinositol 4, Anti-5-bisphosphate 3-kinase catalytic subunit alpha isoform, Anti-PI3-kinase subunit alpha,... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 206,00 €
Anti-PIK3CA
Artikelnummer: E-D-AB-10260L.100
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit,which uses ATP to phosphorylate PtdIns,PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical...
| Schlagworte: | Anti-PIK3CA, Anti-PI3Kalpha, Anti-p110alpha, Anti-PI3K-alpha, Anti-PI3-kinase subunit alpha, Anti-PtdIns-3-kinase subunit... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,rat |
ab 109,00 €
Parsaclisib
Artikelnummer: Cay29784-1
Parsaclisib is an inhibitor of PI3Kdelta (IC50 = 1 nM). It is selective for PI3Kdelta over PI3Kalpha, PI3Kbeta, and PI3Kgamma (IC50s = >10,000 nM for all), as well as a panel of 192 additional kinases and a panel of 70 ion channels and transporters at 1 µM. Parsaclisib inhibits the proliferation of primary human B...
| Schlagworte: | INCB 050465,... |
| Anwendung: | PI3Kdelta inhibitor |
| CAS | 1426698-88-5 |
| MW: | 432.9 D |
ab 103,00 €
Tenalisib
Artikelnummer: Cay30949-10
Tenalisib is an inhibitor of PI3Kdelta and PI3Kgamma (IC50s = 24.5 and 33.2 nM, respectively). It is greater than 300- and 120-fold selective for PI3Kdelta and PI3Kgamma, respectively, over PI3Kalpha and PI3Kbeta. Tenalisib (10 µM) induces cell death in L-540, KM-H2, and L-428 Hodgkin lymphoma cells. It induces cell...
| Schlagworte: | RP 6530, 3-(3-fluorophenyl)-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4H-1-benzopyran-4-one |
| Anwendung: | PI3Kdelta and PI3Kgamma inhibitor |
| CAS | 1639417-53-0 |
| MW: | 415.4 D |
ab 103,00 €
3-Methyladenine
Artikelnummer: TGM-T1879-100mg
Description: 3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kgamma (IC50 = 60 µM) and class III VPS34 (IC50 = 25 µM). 3-Methyladenine inhibits autophagy. Target: PI3K, Autophagy, Mitophagy, Endogenous Metabolite. Smiles: Cn1cnc(N)c2ncnc12. References: Hou H, et al. Inhibitors of...
| Schlagworte: | 3-MA, NSC 66389 |
| Anwendung: | Potent cell permeable and selective PI3 kinase inhibitor |
| CAS | 5142-23-4 |
| MW: | 149.15 D |
ab 37,00 €
Duvelisib
Artikelnummer: TGM-T1988-100mg
Description: Duvelisib (INK1197) is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Target: PI3K. Smiles:...
| Schlagworte: | IPI-145, INK1197 |
| Anwendung: | Targets phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta |
| CAS | 1201438-56-3 |
| MW: | 416.86 D |
ab 42,00 €
PI3K-IN-1
Artikelnummer: TGM-T1826-100mg
Description: PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110gamma , also inhibits DNA-PK and mTOR. Target: PI3K, DNA-PK. Smiles: COc1cc(Nc2nc3ccccc3nc2NS(=O)(=O)c2ccc(NC(=O)c3ccc(OC)c(C)c3)cc2)cc(OC)c1. References: Garcia-Echeverria C, et al. Oncogene, 2008, 27(41), 5511-5526.
| Schlagworte: | SAR245409, XL765, Voxtalisib Analogue, Voxtalisib (SAR245409, XL765) Analogue |
| Anwendung: | PI3K inhibitor |
| CAS | 1349796-36-6 |
| MW: | 599.66 D |
ab 31,00 €
Buparlisib
Artikelnummer: TGM-T1827-100mg
Description: Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110alpha, p110beta, and p110delta). Target: Apoptosis, PI3K. Smiles: Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F. References: Burger MT, et al. Identification of NVP-BKM120 as...
| Schlagworte: | BKM120, NVP-BKM120 |
| Anwendung: | Targets phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta |
| CAS | 944396-07-0 |
| MW: | 410.39 D |
ab 57,00 €