Zu "K00888" wurden 20 Artikel gefunden!
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GSK-F1
Artikelnummer: Cay41366-1
GSK-F1 is a PI4KIIIalpha inhibitor (IC50 = 5.01 nM). It is selective for PI4KIIIalpha over PI4Kbeta, PI3Kalpha, PI3Kbeta, PI3Kdelta, and PI4Kgamma (IC50s = 1,000, 2,512, 7,943, 2,512, and 2,512 nM, respectively). GSK-F1 inhibits the replication of hepatitis C virus (HCV) genotypes 1a, 1b, and 2a in a cell-based...
| Schlagworte: | 5-[2-amino-3,4-dihydro-4-oxo-3-[2-(trifluoromethyl)phenyl]-6-quinazolinyl]-N-(2,4-difluorophenyl)-2-methoxy-3-pyridinesulf... |
| Anwendung: | PI4KA inhibitor |
| CAS | 1402345-92-9 |
| MW: | 603.5 D |
ab 136,00 €
GSK-A1
Artikelnummer: TGM-T27499-1mg
Description: GSK-A1 is a specific inhibitor of PI4KA, also inhibited calcium-driven PRL secretion without affecting calcium signaling and Prl expression. GSK-A1 has anti-hepatitis C virus (HCV) potential. Target: HCV Protease, PI4K. Smiles: COc1ncc(cc1S(=O)(=O)Nc1ccccc1F)-c1ccc2nc(N)n(-c3ccc(cc3)N3CCOCC3)c2c1....
| Anwendung: | PI4KIIIalpha inhibitor |
| CAS | 1416334-69-4 |
| MW: | 574.63 D |
ab 72,00 €
BQR-695
Artikelnummer: TGM-T4220-100mg
Description: BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIbeta and Plasmodium variant of PI4KIIIbeta, respectively. Target: PI3K, PI4K, Parasite. Smiles: CNC(=O)CNc1cnc2ccc(cc2n1)-c1ccc(OC)c(OC)c1. References: Fowler ML, et al. Using hydrogen...
| Schlagworte: | BQR695, NVP-BQR695 |
| Anwendung: | Antimalarial compound, Phosphatidylinositol 4-kinase inhibitor |
| CAS | 1513879-21-4 |
| MW: | 352.39 D |
ab 63,00 €
GSK-F1
Artikelnummer: TGM-T19840-100mg
Description: GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor. Target: PI4K. Smiles: COc1ncc(cc1S(=O)(=O)Nc1ccc(F)cc1F)-c1ccc2nc(N)n(-c3ccccc3C(F)(F)F)c(=O)c2c1. References: Anna Lindsey Banka, et al. Quinazolinone derivatives as antiviral agents.WO2012087938A1
| Schlagworte: | PI4KA inhibitor-F1 |
| Anwendung: | Potent PI4KA inhibitor |
| CAS | 1402345-92-9 |
| MW: | 603.52 D |
ab 112,00 €
GSK-F1
Artikelnummer: SYN-1220-M001
Solid. Soluble in DMSO. GSK-F1 is a potent PI4KA inhibitor. It has better pharmacokinetic properties in vivo than to GSK-A1 (SYN-1219). GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type III? (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for...
| Schlagworte: | 5-(2-Amino-4-oxo-3-(2-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulf... |
| Anwendung: | Potent PI4KA inhibitor |
| CAS | 1402345-92-9 |
| MW: | 603,5 D |
ab 185,00 €
GSK-A1
Artikelnummer: SYN-1219-M001
Solid. Soluble in DMSO. GSK-A1 is a potent PI4KA inhibitor with an IC50 of about 3nM in vitro using HEK-AT1 cells. Phosphatidylinositol 4-kinase type III? (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory...
| Schlagworte: | 5-(2-Amino-1-(4-morpholinophenyl)-1H-benzo[d]imidazol-6-yl)-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide, GSKA1 |
| Anwendung: | Potent PI4KA inhibitor |
| CAS | 1416334-69-4 |
| MW: | 574,6 D |
ab 185,00 €
GSK-A1
Artikelnummer: Cay34502-1
GSK-A1 is an inhibitor of phosphatidylinositol 4-kinase IIIalpha (PI4KIIIalpha, IC50 = 3.16 nM). It is selective for PI4KIIIalpha over PI4KIIIbeta, PI3Kalpha, PI3Kbeta, and PI3Kdelta (IC50s = >50 nM) but also inhibits PI3Kgamma (IC50 = 15.8 nM). GSK-A1 decreases the levels of phosphatidylinositol 4-phosphate...
| Schlagworte: | 5-[2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl]-N-(2-fluorophenyl)-2-methoxy-3-pyridinesulfonamide |
| Anwendung: | PI4KIIIalpha inhibitor |
| CAS | 1416334-69-4 |
| MW: | 574.6 D |
ab 41,00 €
PIK-93
Artikelnummer: LKT-P3542.1
PIK93 is an inhibitor of PI3K that exhibits some selectivity for p110 and p110 . PIK93 also inhibits PI4KIII , a phosphatidylinositol enzyme similar to PI3K. PIK93 decreases translocation of transient receptor potential canonical 6 channel (TRPC6) to the plasma membrane in vitro and may alter Ca2+ signaling as a...
| Schlagworte: | PIK93 |
| Anwendung: | PI4KB inhibitor |
| CAS | 593960-11-3 |
| MW: | 389.88 D |
ab 215,00 €
PIK-93
Artikelnummer: SYN-1066-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. PIK-93 selectively inhibits the type III PI 4-kinase beta enzyme (IC(50) of 19nM). It has also been shown to have activity on PI3Kalpha with an IC(50) of 39nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | PIK93 |
| Anwendung: | PI4KB inhibitor |
| CAS | 593960-11-3 |
| MW: | 389,9 D |
ab 162,00 €
BQR-695
Artikelnummer: Cay27482-1
BQR-695 is an antimalarial compound. It inhibits recombinant P. vivax and human phosphatidylinositol 4-kinase (PI4K, IC50s = 3.5 and 90 nM, respectively). BQR-695 induces schizont-stage arrest and death of P. falciparum (IC50 = ~70 nM) without inducing cytotoxicity in mature red blood cells (RBCs).Formal Name:...
| Schlagworte: | 2-[[7-(3,4-dimethoxyphenyl)-2-quinoxalinyl]amino]-N-methyl-acetamide |
| Anwendung: | Antimalarial compound, Phosphatidylinositol 4-kinase inhibitor |
| CAS | 1513879-21-4 |
| MW: | 352.4 D |
ab 52,00 €
Anti-PI4KA
Artikelnummer: ATA-HPA075515.100
Protein function: Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 100%...
| Schlagworte: | Anti-PIK4, Anti-PI4KA, Anti-PI4K-alpha, Anti-PI4-kinase alpha, Anti-PtdIns-4-kinase alpha, Anti-Phosphatidylinositol... |
| Anwendung: | ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 239,00 €
Human PI4Ka (Phosphatidylinositol-4-Kinase Catalytic...
Artikelnummer: ELK-ELK5139.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PI4Ka. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PI4Ka. Next,...
| Schlagworte: | PIK4, PI4KA, PI4K-alpha, PI4-kinase alpha, PtdIns-4-kinase alpha, Phosphatidylinositol 4-kinase alpha,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 374,00 €