Zu "K00720" wurden 46 Artikel gefunden!
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DL-threo-PPMP (hydrochloride)
Artikelnummer: Cay17236-5
DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin...
| Schlagworte: | DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol,... |
| Anwendung: | Glucosylceramide synthase inhibitor |
| CAS | 139974-41-7 |
| MW: | 511.2 D |
ab 54,00 €
AMP-Deoxynojirimycin
Artikelnummer: TGM-T35626-100mg
Description: AMP-Deoxynojirimycin (AMP-DNM) is a potent inhibitor of ceramide glucosyltransferase and GCase 2, as well as GlcCer biosynthesis, and is utilized in the study of Parkinson's disease and diabetes. Target: Glucosidase, Transferase. Smiles:...
| Schlagworte: | AMP-DNM |
| Anwendung: | Glucosylceramide synthase inhibitor |
| CAS | 216758-20-2 |
| MW: | 397.55 D |
ab 96,00 €
Glucocerebrosides
Artikelnummer: TGM-T36581-1mg
Description: Glucocerebrosides is a natural product. Target: Others. References: Sperling P, et al. Are glucocerebrosides the predominant sphingolipids in plant plasma membranes? Plant Physiol Biochem. 2005 Dec,43(12):1031-8.
| Anwendung: | Glucocerebroside mixture |
| CAS | 497155-61-0 |
96,00 €
Glucocerebrosides (Gaucher's spleen)
Artikelnummer: TGM-T36582-10mg
Description: Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species. Glucocerebrosides are precursors in the synthesis of lactosylceramides...
| Anwendung: | Lactosylceramide & ganglioside precursor |
| CAS | 85305-87-9 |
| MW: | 812.3 D |
ab 181,00 €
Eliglustat
Artikelnummer: TGM-T3663-100mg
Description: Eliglustat (Genz 99067) is an oral inhibitor of glucosylceramide synthase which is used in the therapy of type 1 Gaucher disease. Target: Transferase. Smiles: CCCCCCCC(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc2OCCOc2c1. References: Shayman JA. Drugs Future. 2010, 35(8):613-620.
| Schlagworte: | Genz 99067, GENZ-112638 |
| Anwendung: | Targets ceramide glucosyltransferase [EC:2.4.1.80] (UGCG) |
| CAS | 491833-29-5 |
| MW: | 404.54 D |
ab 52,00 €
D-threo-PPMP
Artikelnummer: TGM-T38822-5mg
Description: D-threo-PPMP, a powerful glucosylceramide (GlcCer) synthase inhibitor, effectively impedes karyokinesis and decreases cyst formation. Target: Others. Smiles: CCCCCCCCCC CCCCCC(=O)N[C@H](CN1CCOCC1)[C@H](O)c1ccccc1. References: Gouazé V, et, al. Glucosylceramide synthase blockade down-regulates...
| Anwendung: | Glucosylceramide synthase inhibitor control (inactive) |
| CAS | 139889-53-5 |
| MW: | 474.73 D |
951,00 €
L-threo-PPMP
Artikelnummer: TGM-T39478-5mg
Description: L-threo-PPMP is an inhibitor of GlcT, which is the UDP-Glc: Ceramide beta1,1glucosyltransferase enzyme. It effectively inhibits glycosphingolipid biosynthesis, while also inducing apoptosis. These properties of L-threo-PPMP contribute to its notable anti-cancer activity. Target: Others. Smiles:...
| Anwendung: | Glucosylceramide synthase inhibitor control (inactive) |
| CAS | 207278-87-3 |
| MW: | 474.73 D |
951,00 €
D-threo-PPMP hydrochloride
Artikelnummer: TGM-T36974-10mg
Description: D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 µM and significantly inhibits DNA...
| Anwendung: | Glucosylceramide (GlyCer) synthetase inhibitor |
| CAS | 139889-65-9 |
| MW: | 511.19 D |
ab 514,00 €
(+)-D-threo-PDMP (hydrochloride)
Artikelnummer: TGM-T37551-10mg
Description: (+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP . (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 50% when used at a concentration of 5 µM in an enzyme assay. (+)-D-threo-PDMP is the active component of...
| Anwendung: | Glucosylceramide (GlyCer) synthetase inhibitor |
| CAS | 139889-62-6 |
| MW: | 427.03 D |
1.147,00 €
D,L-erythro-PDMP
Artikelnummer: TGM-T38489-5mg
Description: D,L-erythro-PDMP, an erythro isomer of PDMP, exhibits growth inhibition on cultured rabbit skin fibroblasts. Additionally, this compound serves as an effective inhibitor of UDP-glucose: ceramide glucosyltransferase. Target: Others. Smiles: CCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@@H](O)c1ccccc1. References:...
| Anwendung: | Cell growth inhibitor |
| CAS | 109760-77-2 |
| MW: | 390.568 D |
951,00 €
Genz-123346 free base
Artikelnummer: TGM-T4049-100mg
Description: Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1. Target: Glucokinase. Smiles: CCCCCCCCC(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc2OCCOc2c1. References: Zhao H, et al. Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal...
| Anwendung: | Glucosylceramide synthase (ceramide glucosyltransferase) inhibitor |
| CAS | 491833-30-8 |
| MW: | 418.57 D |
ab 43,00 €
Ibiglustat
Artikelnummer: TGM-T4473-100mg
Description: Ibiglustat (GZ402671) is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. Ibiglustat blocks the formation of glucosylceramide (GL-1), a key intermediate in the synthesis of GL-3. Ibiglustat is potentially useful for treating Fabry disease. Fabry...
| Schlagworte: | Venglustat, SAR402671, GZ402671 |
| Anwendung: | Targets ceramide glucosyltransferase [EC:2.4.1.80] (UGCG) |
| CAS | 1401090-53-6 |
| MW: | 389.49 D |
ab 54,00 €