Zu "K00560" wurden 88 Artikel gefunden!
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Raltitrexed
Artikelnummer: TGM-T6632-100mg
Description: Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth. Target: DNA/RNA Synthesis, Nucleoside Antimetabolite/Analog. Smiles: O=C1C=2C(=CC=C(CN(C)C=3SC(C(N[C@@H](CCC(O)=O)C(O)=O)=O)=CC3)C2)NC(C)=N1. References: Peters GJ, et al. Eur J Cancer,...
| Schlagworte: | Tomudex, ZD1694, D1694, ICI-D1694 |
| Anwendung: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 112887-68-0 |
| MW: | 458.49 D |
ab 31,00 €
Capecitabine
Artikelnummer: TGM-T1408-1g
Description: Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU), subsequently, 5-FU is metabolized to two active...
| Schlagworte: | Capiibine, RO 09-1978, Capecitibine, Xeloda |
| Anwendung: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 154361-50-9 |
| MW: | 359.35 D |
ab 46,00 €
Carmofur
Artikelnummer: TGM-T1307-100mg
Description: Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy. Target: DNA/RNA Synthesis, SARS-CoV, Nucleoside Antimetabolite/Analog, Virus Protease. Smiles: CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O....
| Schlagworte: | HCFU |
| Anwendung: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 61422-45-5 |
| MW: | 257.26 D |
ab 31,00 €
Plevitrexed
Artikelnummer: TGM-T12635L-100mg
Description: Plevitrexed is taken up via the alpha-folate receptor as well as the reduced folate carrier. Plevitrexed is an orally active and effective thymidylate synthase (TS) inhibitor (Ki: 0.44 nM). Plevitrexed is used for gastric cancer in clinical. Target: Others. Smiles:...
| Schlagworte: | BGC9331, ZD 9331 |
| Anwendung: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 153537-73-6 |
| MW: | 532.53 D |
ab 3.323,00 €
Tegafur
Artikelnummer: TGM-T1378-100mg
Description: Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Target: DNA/RNA Synthesis, Nucleoside Antimetabolite/Analog. Smiles: O=C1N(C=C(F)C(=O)N1)C2CCCO2....
| Schlagworte: | FT 207, NSC 148958, FT-207, Fluorafur |
| Anwendung: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 17902-23-7 |
| MW: | 200.17 D |
ab 38,00 €
Trifluridine
Artikelnummer: TGM-T1428-100mg
Description: Trifluridine (NSC-75520) is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral...
| Schlagworte: | Trifluorothymidine, 5-Trifluorothymidine, NSC 75520, NSC 529182, Trifluridina, Viroptic |
| Anwendung: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 70-00-8 |
| MW: | 296.2 D |
ab 31,00 €
Nolatrexed dihydrochloride
Artikelnummer: TGM-T2627-10mg
Description: Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine...
| Schlagworte: | Thymitaq, AG 337 |
| Anwendung: | Thymidylate synthase inhibitor |
| CAS | 152946-68-4 |
| MW: | 357.26 D |
ab 40,00 €
(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
Artikelnummer: TGM-T35413-10mg
Description: (6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines,...
| Anwendung: | Tetrahydrofolic acid diastereomer |
| CAS | 150731-85-4 |
| MW: | 481.89 D |
ab 98,00 €
Fosifloxuridine nafalbenamide
Artikelnummer: TGM-T33762-100mg
Description: Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher concentrations of FUDR-MP in patients' cells. Target: DNA/RNA Synthesis. Smiles:...
| Schlagworte: | NUC-3373, NUC3373, NUC 3373 |
| Anwendung: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 1332837-31-6 |
| MW: | 613.53 D |
ab 81,00 €
Vanoxonin
Artikelnummer: TGM-T26315-25mg
Description: Vanoxonin is a new thymidylate synthetase inhibitor. Target: Others. Smiles: C(N[C@H](C(N[C@@H](CCCN(C(C)=O)O)C(O)=O)=O)[C@@H](C)O)(=O)C1=C(O)C(O)=CC=C1. References: Kanai F, Isshiki K, Umezawa Y, Morishima H, Naganawa H, Takita T, Takeuchi T, Umezawa H. Vanoxonin, a new inhibitor of thymidylate...
| Schlagworte: | MG-245-CF2-A, Antibiotic MG 245CF2A |
| Anwendung: | Bioctive bacterial metabolite |
| CAS | 86933-99-5 |
| MW: | 427.41 D |
ab 2.272,00 €
Arfolitixorin
Artikelnummer: TGM-T26654-25mg
Description: Arfolitixorin is an antifolate modulator. Target: Others. Smiles: O=C1C=2N3[C@@](CN(C3)C4=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C4)(CNC2NC(N)=N1)[H]
| Anwendung: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 31690-11-6 |
| MW: | 457.44 D |
ab 1.520,00 €
5,6-dihydro-5-Fluorouracil
Artikelnummer: TGM-T36870-10mg
Description: 5,6-dihydro-5-Fluorouracil (5-FUH2) is an inactive metabolite of 5-FU and can be used for the study of organismal metabolism. Target: Others. Smiles: FC1CNC(=O)NC1=O. References: McQuade RM, et al. Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer...
| Schlagworte: | 5-fluorodihydrouracil, 5-Fluoro-dihydro-pyrimidine-2,4-dione |
| Anwendung: | Apoptosis inducer |
| CAS | 696-06-0 |
| MW: | 132.09 D |
ab 222,00 €