Zu "K00512" wurden 61 Artikel gefunden!
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Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1),...
Artikelnummer: CSB-EP006392HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: AKKT+24-508aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: AKKTGAKYPK SLLSLPLVGS LPFLPRHGHM HNNFFKLQKK YGPIYSVRMG TKTTVIVGHH QLAKEVLIKK GKDFSGRPQM ATLDIASNNR KGIAFADSGA HWQLHRRLAM ATFALFKDGD QKLEKIICQE...
| Schlagworte: | CYP17, CYPXVII, Cytochrome P450c17, Cytochrome P450-C17, Cytochrome P450 17A1, Steroid 17-alpha-monooxygenase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 58.6 kD |
ab 219,00 €
Orteronel
Artikelnummer: TGM-T6051-100mg
Description: Orteronel ((S)-Orteronel)(TAK-700) was selected as a candidate for clinical evaluation. orteronel (TAK-700) is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer. Target: P450. Smiles: CNC(=O)c1ccc2cc(ccc2c1)[C@@]1(O)CCn2cncc12. References: Yamaoka M, et al....
| Schlagworte: | (S)-Orteronel, TAK-700 |
| Anwendung: | Targets steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase (CYP17A) |
| CAS | 566939-85-3 |
| MW: | 307.35 D |
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Abiraterone Acetate
Artikelnummer: TGM-T6215-100mg
Description: Abiraterone Acetate (CB7630) is an androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLA STICAGENT in the treatment of metastatic castration-resistant PROSTATE CANCER. Target: P450. Smiles:...
| Schlagworte: | Zytiga, CB7630 |
| Anwendung: | Targets steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase (CYP17A) |
| CAS | 154229-18-2 |
| MW: | 391.55 D |
ab 31,00 €
Abiraterone
Artikelnummer: TGM-T6216-100mg
Description: Abiraterone (CB-7598) (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50: 4 nM). Target: P450. Smiles: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC=C2C=5C=CC=NC5)[H]. References: Attard G, et al. J Clin Oncol. 2008,...
| Schlagworte: | CB-7598 |
| Anwendung: | CYP17A1 inhibitor |
| CAS | 154229-19-3 |
| MW: | 349.51 D |
ab 34,00 €
CYP17A1 Protein, Human, Recombinant (GST)
Artikelnummer: TGM-TMPH-02139-100ug
Description: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as...
| Schlagworte: | Cytochrome P450 17A1, CYPXVII, 17-alpha-hydroxyprogesterone aldolase, Steroid 17-alpha-monooxygenase, Steroid... |
| MW: | 84.4 kD |
ab 198,00 €
Galeterone
Artikelnummer: TGM-T6509-100mg
Description: Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing...
| Schlagworte: | VN-124-1, VN/124-1, VN 124, TOK-001 |
| Anwendung: | Targets steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase (CYP17A) |
| CAS | 851983-85-2 |
| MW: | 388.55 D |
ab 52,00 €
Mitotane
Artikelnummer: TGM-T1199-100mg
Description: Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODI PHENYLDICH LOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. Target: AChR, Apoptosis....
| Schlagworte: | Mitotan, NCI-C04933, o,p'-DDD, 2,4'-DDD |
| Anwendung: | Targets steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase (CYP17A) |
| CAS | 53-19-0 |
| MW: | 320.04 D |
ab 31,00 €
Anti-CYP17A1
Artikelnummer: CSB-PA007590.50
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-CYP17, Anti-CYPXVII, Anti-Cytochrome P450c17, Anti-Cytochrome P450-C17, Anti-Cytochrome P450 17A1, Anti-Steroid... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
126,00 €
Anti-CYP17A1
Artikelnummer: CSB-PA074176.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CYP17A1. Antigen Species: Human
| Schlagworte: | Anti-CYP17, Anti-CYPXVII, Anti-Cytochrome P450c17, Anti-Cytochrome P450-C17, Anti-Cytochrome P450 17A1, Anti-Steroid... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Anti-CYP17A1
Artikelnummer: CSB-PA939101.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: CYP17A1. Antigen Species: Human
| Schlagworte: | Anti-CYP17, Anti-CYPXVII, Anti-Cytochrome P450c17, Anti-Cytochrome P450-C17, Anti-Cytochrome P450 17A1, Anti-Steroid... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1),...
Artikelnummer: CSB-EP006392HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-508aa. Protein Length: Full Length. Tag Info: N-terminal GST-tagged. Target Protein Sequence: MWELVALLLL TLAYLFWPKR RCPGAKYPKS LLSLPLVGSL PFLPRHGHMH NNFFKLQKKY GPIYSVRMGT KTTVIVGHHQ LAKEVLIKKG KDFSGRPQMA TLDIASNNRK GIAFADSGAH WQLHRRLAMA TFALFKDGDQ...
| Schlagworte: | CYP17, CYPXVII, Cytochrome P450c17, Cytochrome P450-C17, Cytochrome P450 17A1, Steroid 17-alpha-monooxygenase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 84.4 kD |
ab 219,00 €
Steroid 17-alpha-hydroxylase/17,20 lyase (Cyp17a1), rat,...
Artikelnummer: CSB-EP006392RA.1
Organism: Rattus norvegicus (Rat). Source: E.coli. Expression Region: 1-507aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: MWELVGLLLL ILAYFFWVKS KTPGAKLPRS LPSLPLVGSL PFLPRRGHMH VNFFKLQEKY GPIYSLRLGT TTTVIIGHYQ LAREVLIKKG KEFSGRPQMV TQSLLSDQGK GVAFADAGSS WHLHRKLVFS...
| Schlagworte: | Cyp17, CYPXVII, Cyp17a1, Cytochrome P450c17, Cytochrome P450-C17, Cytochrome P450 17A1, Steroid 17-alpha-monooxygenase,... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | rat |
| MW: | 73.3 kD |
ab 364,00 €