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Zu "K00511" wurden 40 Artikel gefunden!
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Artikelnummer: TGM-T6702-100mg
Description: Terbinafine (TDT 067) is a synthetic allylamine derivative with antifungal activity. Terbinafine exerts its effect through inhibition of squalene epoxidase, thereby blocking the biosynthesis of ergosterol, an important component of fungal cell membranes. As a result, this agent disrupts fungal cell...
Schlagworte: | SF 86-327, Terbinex, Lamisil, TDT 067 |
Anwendung: | Targets squalene monooxygenase [EC:1.14.14.17] (SQLE, ERG1) |
CAS | 91161-71-6 |
MW: | 291.43 D |
ab 40,00 €
Artikelnummer: TGM-T1217-1g
Description: Butenafine hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, inhibiting the synthesis of sterols by inhibiting squalene epoxidase. Target: Antibiotic, Antifungal. Smiles: Cl.C(c1ccc(cc1)CN(C)Cc1cccc2c1cccc2)(C)(C)C. References: Kokjohn K, et al. Int J Dermatol, 2003, 42, 11-17.
Schlagworte: | KP-363, KP363 (Hydrochloride), Butenafine HCl |
Anwendung: | Targets squalene monooxygenase [EC:1.14.14.17] (SQLE, ERG1) |
CAS | 101827-46-7 |
MW: | 353.93 D |
ab 31,00 €
Artikelnummer: TGM-T1497-100mg
Description: Liranaftate (Piritetrate) is a thiocarbamate and squalene epoxidase inhibitor with antifungal activity. Liranaftate inhibits fungal squalene epoxidase, an enzyme that plays a key role in the synthesis of sterol which is essential for cell membrane integrity. By preventing ergosterol synthesis and...
Schlagworte: | Piritetrate, M-732 |
Anwendung: | Targets squalene monooxygenase [EC:1.14.14.17] (SQLE, ERG1) |
CAS | 88678-31-3 |
MW: | 328.43 D |
ab 49,00 €
Artikelnummer: TGM-T24893-100mg
Description: Tolciclate is an agent of antifungal medication. Target: Others. Smiles: O(C(N(C)C1=CC(C)=CC=C1)=S)C=2C=C3C(C4CC3CC4)=CC2. References: Cucè LC, Assunção BF, Medawar LG, Salibian A, Groppi W. Tolciclate versus miconazole, a double-blind trial in patients with dermatomycosis. J Int Med Res....
Anwendung: | Targets squalene monooxygenase [EC:1.14.14.17] (SQLE, ERG1) |
CAS | 50838-36-3 |
MW: | 323.45 D |
ab 1.520,00 €
Artikelnummer: TGM-T21365-25mg
Description: Butenafine hydrochloride is a hydrochloride of butenafine, which inhibits squalene epoxidase to inhibit the synthesis of ergosterol, leading to the increased permeability of the cell membranes, allowing their contents to leak out. Target: Others. Smiles: C=1C=CC2=C(C1)C=CC=C2CN(C)CC3=CC=C(C=C3)C(C)(C)C....
Schlagworte: | KP-363, Butop, KP 363, Mentax, KP363 |
Anwendung: | Targets squalene monooxygenase [EC:1.14.14.17] (SQLE, ERG1) |
CAS | 101828-21-1 |
MW: | 317.47 D |
1.520,00 €
Artikelnummer: TGM-T3795-100mg
Description: Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B hepatoma cells.Corilagin has antiviral activity, reduces the cytotoxicity induced...
Anwendung: | Squalene epoxidase inhibitor |
CAS | 23094-69-1 |
MW: | 634.45 D |
ab 43,00 €
Artikelnummer: TGM-TMID-0249-1mg
Description: Terbinafine-d3 hydrochloride is a deuterated compound of Terbinafine hydrochloride. Terbinafine hydrochloride has a CAS number of 78628-80-5. Terbinafine Hydrochloride is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes. Smiles:...
Anwendung: | GC-MS, LC-MS, quantification, internal standard, antifungal, ergosterol biosynthesis inhibitor |
CAS | 1310012-15-7 |
MW: | 330.91 D |
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Artikelnummer: TGM-TQ0115-100mg
Description: NB-598 is an effective and competitive inhibitor of squalene epoxidase. It suppresses triglyceride biosynthesis through the farnesol pathway. Target: Antifungal. Smiles: CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCc2cc(cs2)-c2ccsc2)c1. References: Horie M, et al. Effects of NB-598, a potent squalene epoxidase...
Anwendung: | Squalene epoxidase inhibitor |
CAS | 131060-14-5 |
MW: | 449.67 D |
ab 72,00 €
Artikelnummer: CSB-EP613505HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 42-574aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: LSYRCRHRNG GLLGRQQSGS QFALFSDILS GLPFIGFFWA KSPPESENKE QLEARRRRKG TNISETSLIG TAACTSTSSQ NDPEVIIVGA GVLGSALAAV LSRDGRKVTV IERDLKEPDR IVGEFLQPGG YHVLKDLGLG...
Schlagworte: | SE, SQLE, ERG1, Squalene epoxidase, Squalene monooxygenase, Recombinant Human Squalene monooxygenase (SQLE), partial |
Anwendung: | Activity not tested |
Exprimiert in: | E.coli |
Ursprungsart: | human |
MW: | 63.3 kD |
ab 292,00 €
Artikelnummer: Cay10011619-100
Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. metagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 µg/ml). It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 µM,...
Schlagworte: | N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine, monohydrochloride |
Anwendung: | Antifungal compound, ergosterol biosynthesis inhibitor |
CAS | 78628-80-5 |
MW: | 327.9 D |
ab 100,00 €
Artikelnummer: Cay19234-50
Naftifine is an allylamine compound that blocks ergosterol biosynthesis in fungi by inhibiting squalene epoxidase (Ki = 1.1 µM for C. albicans epoxidase).Formal Name: N-methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-1-naphthalenemethanamine, monohydrochloride. CAS Number: 65473-14-5. Synonyms: AW 105-843. Molecular Formula:...
Schlagworte: | AW 105-843, N-methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-1-naphthalenemethanamine, monohydrochloride |
Anwendung: | Squalene epoxidase inhibitor |
CAS | 65473-14-5 |
MW: | 323.9 D |
ab 53,00 €
Artikelnummer: Cay26077-100
Amorolfine is an antifungal. It is active against isolates of T. rubrum, T. mentagrophytes, and C. albicans (MIC90s = 4-15, 4-60, and =30-500 ng/ml, respectively). It inhibits the growth of T. mentagrophytes and T. rubrum by 33.7 and 38.5%, respectively, in an in vitro bovine hoof model of onychomycosis. Amorolfine...
Schlagworte: | Ro 14-4767/002, (2R,6S)-rel-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine, monohydrochloride |
Anwendung: | Antifungal, ergosterol biosynthesis inhibitor |
CAS | 78613-38-4 |
MW: | 354 D |
ab 85,00 €