Zu "K00509" wurden 235 Artikel gefunden!
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Licofelone
Artikelnummer: Cay10007692-10
Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1beta (IL-1beta) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO)...
| Schlagworte: | ML 3000, 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic acid |
| Anwendung: | COX-1/COX-2/5-LO dual inhibitor |
| CAS | 156897-06-2 |
| MW: | 379.9 D |
ab 69,00 €
COX (human) Inhibitor Screening Assay Kit
Artikelnummer: Cay701230-96
The COX (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2a. This assay includes recombinant human COX-1 and COX-2 and is an excellent tool...
| Schlagworte: | Cyclooxygenase (human) Inhibitor Screening Assay Kit |
| Anwendung: | Inhibitor screening |
| Spezies-Reaktivität: | human |
597,00 €
SC-560
Artikelnummer: Cay70340-1
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex(TM)) and rofecoxib (Vioxx(TM)). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect...
| Schlagworte: | 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole |
| Anwendung: | COX-1 inhibitor |
| CAS | 188817-13-2 |
| MW: | 352.7 D |
ab 27,00 €
COX-1 (human) Inhibitor Screening Assay Kit
Artikelnummer: Cay701070-96
The COX-1 (human) Inhibitor Screening Assay directly measures PGF2alpha by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2alpha. This assay includes recombinant human COX-1 and is an excellent tool for...
| Schlagworte: | Cyclooxygenase 1 |
| Anwendung: | Inhibitor screening |
| Spezies-Reaktivität: | human |
597,00 €
COX-1 (ovine)
Artikelnummer: Cay60100-5
Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities. It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail. COX-1 is constitutively expressed in the gastrointestinal tract, kidney,...
| Schlagworte: | COX1, PTGS1, COX-1, PHS 1, COX-1, PHS 1, PGHS-1, PGHS-1, PGH synthase 1, PGH synthase 1, Cyclooxygenase-1,... |
| Anwendung: | Enzyme activity |
1.123,00 €
COX Colorimetric Inhibitor Screening Assay Kit
Artikelnummer: Cay701050-192
The COX Colorimetric Inhibitor Screening Assay measures the peroxidase component of cyclooxygenases. The peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) at 590 nm. Inhibition of COX activity, measured by TMPD oxidation, by a...
| Anwendung: | Inhibitor screening |
1.072,00 €
MefenaMic Acid-d4
Artikelnummer: TGM-TMIH-0325-1mg
Description: MefenaMic Acid-d4 is a deuterated compound of MefenaMic Acid. MefenaMic Acid has a CAS number of 61-68-7. Mefenamic acid is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase. Smiles:...
| Anwendung: | GC-MS, LC-MS, quantification, internal standard, COX inhibitor |
| CAS | 1216745-79-7 |
| MW: | 245.31 D |
ab 195,00 €
Diclofenac-d4
Artikelnummer: TGM-TMIJ-0127-1mg
Description: Diclofenac-d4 is a deuterated compound of Diclofenac. Diclofenac has a CAS number of 15307-86-5. Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of...
| Anwendung: | Standard, COX-1/2 inhibitor |
| CAS | 153466-65-0 |
| MW: | 300.17 D |
Bitte fragen Sie den aktuellen Preis für diesen Artikel an.
Flunixin-d3 (methyl-d3)
Artikelnummer: TGM-TMIJ-0298-1mg
Description: Flunixin-d3 (methyl-d3) is a deuterated compound of Flunixin. Flunixin has a CAS number of 38677-85-9. Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), antipyretic, and analgesic used in pigs, horses, and cattle. Smiles: FC(C1C=CC=C(C=1C([2H])([2H])[2H])NC1=C(C=CC=N1)C(O)=O)(F)F
| Anwendung: | GC-MS, LC-MS internal standard, quantification, NSAID |
| CAS | 1015856-60-6 |
| MW: | 299.26 D |
Bitte fragen Sie den aktuellen Preis für diesen Artikel an.
Piketoprofen
Artikelnummer: TGM-T25956-100mg
Description: Piketoprofen (Calmatel) is a topical nonsteroidal anti-inflammatory agent. Target: Others. Smiles: CC(C(=O)Nc1cc(C)ccn1)c1cccc(c1)C(=O)c1ccccc1. References: Fernández-Jorge B, Goday Buján JJ, Paradela S, Mazaira M, Fonseca E. Consort photocontact dermatitis from piketoprofen. Contact Dermatitis. 2008...
| Schlagworte: | Calmatel |
| Anwendung: | Targets prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1] (PTGS1, COX1) |
| CAS | 60576-13-8 |
| MW: | 344.41 D |
ab 74,00 €
Amtolmetin guacil
Artikelnummer: TGM-T19672-100mg
Description: Amtolmetin guacil (ST-679) inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties. Target: COX. Smiles: COc1ccccc1OC(=O)CNC(=O)Cc1ccc(C(=O)c2ccc(C)cc2)n1C. References: De...
| Schlagworte: | ST679, ST-679, MED-15, ST 679, MED15, MED 15 |
| Anwendung: | Targets prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1] (PTGS1, COX1) |
| CAS | 87344-06-7 |
| MW: | 420.46 D |
ab 31,00 €
Ampiroxicam
Artikelnummer: TGM-T6387-100mg
Description: Ampiroxicam (Flucam) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. Target: COX. Smiles: CCOC(=O)OC(C)OC1=C(N(C)S(=O)(=O)c2ccccc12)C(=O)Nc1ccccn1. References: Abdelrahim M, et al. J Natl Cancer Inst, 2006, 98(12), 855-868.
| Schlagworte: | CP 65703, Flucam |
| Anwendung: | Targets prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1] (PTGS1, COX1) |
| CAS | 99464-64-9 |
| MW: | 447.46 D |
ab 34,00 €