Zu "K00458" wurden 34 Artikel gefunden!
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2-TEDC
Artikelnummer: Cay41872-10
2-TEDC is a lipoxygenase (LO) inhibitor (IC50s = 0.09, 0.013, and 0.5 µM for 5-, 12-, and 15-LO, respectively). It prevents axon degeneration induced by withdrawal of nerve growth factor (NGF) in primary rat dorsal root ganglion neurons (mean EC50 = 2.79 µM). 2-TEDC also inhibits severe acute respiratory syndrome...
| Schlagworte: | EDC, ethyl 3,4-Dihydroxybenzylidenecyanoacetate, 2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid, 2-(2-thienyl) ethyl ester |
| Anwendung: | Lipoxygenase inhibitor |
| CAS | 132465-10-2 |
| MW: | 315.3 D |
ab 40,00 €
Baicalein
Artikelnummer: TGM-T2858-100mg
Description: Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor. Target: ROS, Xanthine Oxidase, Ferroptosis, Influenza Virus. Smiles: O.Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1. References: Ma X, et al. Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1...
| Schlagworte: | 5,6,7-Trihydroxyflavone |
| Anwendung: | Lipid peroxidation inhibitor |
| CAS | 491-67-8 |
| MW: | 270.24 D |
ab 33,00 €
ML355
Artikelnummer: TGM-T4347-100mg
Description: ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 µM), possess favorable ADME properties. Target: Lipoxygenase. Smiles: COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2nc3ccccc3s2)c1O. References: Luci DK, et al. Synthesis and structure-activity relationship studies of...
| Anwendung: | 12-LO inhibitor |
| CAS | 1532593-30-8 |
| MW: | 441.52 D |
ab 42,00 €
CAY10698
Artikelnummer: TGM-T8950-100mg
Description: CAY10698 is a 12-lipoxygenase inhibitor (12-LO, IC50 of 5.1 µM). Target: Lipoxygenase. Smiles: COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2nccs2)c1O. References: Chen, X.-S., Kurre, U., Jenkins, N.A., et al. cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal...
| Anwendung: | 12-LO inhibitor |
| CAS | 684236-01-9 |
| MW: | 391.46 D |
ab 40,00 €
ALOX12 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-00955-100ug
Description: ALOX12 Protein, Human, Recombinant (His) is expressed in E. coli.
| Schlagworte: | 12LO, 12S-lipoxygenase, 12S-LOX, Linoleate (13S)-lipoxygenase, Platelet-type lipoxygenase 12, Arachidonate... |
| MW: | 79.8 kD |
ab 278,00 €
Arachidonate 12-lipoxygenase, 12S-type (ALOX12), human,...
Artikelnummer: CSB-EP001617HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-663aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MGRYRIRVAT GAWLFSGSYN RVQLWLVGTR GEAELELQLR PARGEEEEFD HDVAEDLGLL QFVRLRKHHW LVDDAWFCDR ITVQGPGACA EVAFPCYRWV QGEDILSLPE GTARLPGDNA LDMFQKHREK...
| Schlagworte: | 12LO, 12S-LOX, EC=3.3.2.-, 12S-lipoxygenase, Lipoxin synthase 12-LO, Linoleate (13S)-lipoxygenase, Platelet-type... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 79.8 kD |
ab 283,00 €
ML-355
Artikelnummer: Cay18537-1
Platelet-type 12-lipoxygenase (12-LO, Cay-10341) catalyzes the formation of 12-HpETE (Cay-44570) from arachidonic acid (Cay-90010). It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines. It has also been implicated in the modulation of...
| Schlagworte: | N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-benzenesulfonamide |
| Anwendung: | 12-LO inhibitor |
| CAS | 1532593-30-8 |
| MW: | 441.5 D |
ab 66,00 €
Baicalein
Artikelnummer: Cay70610-50
Baicalein is a flavonoid originally isolated from the roots of S. baicalensis that has diverse biological activities. It inhibits human platelet 12-lipoxygenase (12-LO) and human reticulocyte 15-LO-1 (IC50s = 0.64 and 1.6 µM, respectively) but is less potent at 15-LO-1 when the detergent Triton-X is present (IC50 =...
| Schlagworte: | 5,6,7-trihydroxyflavone |
| Anwendung: | Lipid peroxidation inhibitor |
| CAS | 491-67-8 |
| MW: | 270.2 D |
ab 24,00 €
Human ALOX12 (Arachidonate-12-Lipoxygenase) ELISA Kit
Artikelnummer: ELK-ELK4754.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ALOX12. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ALOX12....
| Schlagworte: | 12LO, 12S-LOX, EC=3.3.2.-, 12S-lipoxygenase, Lipoxin synthase 12-LO, Linoleate (13S)-lipoxygenase, Platelet-type... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
5,8,11-Eicosatriynoic Acid
Artikelnummer: Cay90200-5
5,8,11-ETI is a nonselective inhibitor of lipoxygenases. It inhibits 12-LO in human platelets with an ID50 value of 24 µM. 5,8,11-ETI also inhibits A23187 and L-cysteine induced LTC4 biosynthesis in mouse mastocytoma cells with an ID50 value of 5 µM. At higher concentrations, 5,8,11-ETI also inhibits cyclooxygenases...
| Schlagworte: | 5,8,11-ETI, 5,8,11-eicosatriynoic acid |
| Anwendung: | LO inhibitor |
| CAS | 13488-22-7 |
| MW: | 300.4 D |
ab 114,00 €
12-Lipoxygenase (platelet-type, mouse recombinant)
Artikelnummer: Cay10341-25
12-Lipoxygenase (12-LO) catalyzes the formation of 12-HpETE from arachidonic acid. There are two main types of 12-LO, platelet-type and leukocyte-type, which share only 60% identity at the amino acid level and strongly differ in substrate specificity and enzyme kinetics. Leukocyte-type 12-LO has the ability to also...
| Schlagworte: | Alox12, P-12LO, P-12LO, Alox12p, 12S-LOX, 12S-LOX, 12S-lipoxygenase, 12S-lipoxygenase, Lipoxin synthase 12-LO, Lipoxin... |
| Anwendung: | Enzyme activity |
| MW: | 76,4 kD |
489,00 €
CAY10698
Artikelnummer: Cay18582-1
Platelet-type 12-lipoxygenase (12-LO, Cay-10341) catalyzes the formation of 12-HpETE (Cay-44570) from arachidonic acid (Cay-90010). It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines. It has also been implicated in the modulation of...
| Schlagworte: | 4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-N-2-thiazolyl-benzenesulfonamide |
| Anwendung: | 12-LO inhibitor |
| CAS | 684236-01-9 |
| MW: | 391.5 D |
ab 43,00 €