Zu "K00254" wurden 61 Artikel gefunden!
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Brequinar
Artikelnummer: TGM-T5013-100mg
Description: Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses. Target: Dehydrogenase, DNA/RNA Synthesis, Virus Protease. Smiles: Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F. References: Qing M, et al. Characterization of...
| Schlagworte: | Bipenquinate, NSC 368390, DUP785 |
| Anwendung: | DHODH inhibitor |
| CAS | 96187-53-0 |
| MW: | 375.37 D |
ab 41,00 €
Teriflunomide
Artikelnummer: TGM-T7534-100mg
Description: Teriflunomide (A 77-1726) is the principal active metabolite of leflunomide, an approved therapy for rheumatoid arthritis and multiple sclerosis. Target: Others. Smiles: C(F)(F)(F)C1=CC=C(NC(/C(=C(/C)\O)/C#N)=O)C=C1. References: Paul O , Oh . An update of teriflunomide for treatment of multiple...
| Schlagworte: | A 77-1726 |
| Anwendung: | Targets dihydroorotate dehydrogenase [EC:1.3.5.2] (DHODH, pyrD) |
| CAS | 163451-81-8 |
| MW: | 270.21 D |
ab 45,00 €
AG-636
Artikelnummer: TGM-T9121-100mg
Description: AG-636 is a potent, reversible, and selective DHODH inhibitor with an IC50 of 17 nM and is orally active. It demonstrates strong anticancer effects. Target: DNA/RNA Synthesis, Dehydrogenase. Smiles: Cc1ccccc1-c1ccc(cc1)-c1cc(C(O)=O)c2n(C)nnc2c1. References: Gabrielle McDonald, et al. Selective...
| Anwendung: | DHODH inhibitor |
| CAS | 1623416-31-8 |
| MW: | 343.38 D |
ab 67,00 €
DHODH Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01225-100ug
Description: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
| Schlagworte: | Dihydroorotate dehydrogenase (quinone), mitochondrial, DHODH, Dihydroorotate oxidase, DHOdehase |
| MW: | 45.1 kD |
ab 193,00 €
Leflunomide-d4
Artikelnummer: TGM-TMID-0237-1mg
Description: Leflunomide-d4 is a deuterated compound of Leflunomide. Leflunomide has a CAS number of 75706-12-6. Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis. Smiles: C(NC1=C(C(=C(C(F)(F)F)C(=C1[2H])[2H])[2H])[2H])(=O)C2=C(C)ON=C2
| Anwendung: | GC-MS, LC-MS, quantification, internal standard, dihydroorotate dehydrogenase inhibitor |
| CAS | 1189987-23-2 |
| MW: | 274.23 D |
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DHODH Protein, Mouse, Recombinant (E. coli, His)
Artikelnummer: TGM-TMPH-02627-100ug
Description: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
| Schlagworte: | DHODH, Dihydroorotate oxidase, Dihydroorotate dehydrogenase (quinone), mitochondrial, DHOdehase |
| MW: | 45.0 kD |
ab 232,00 €
DHODH Protein, Mouse, Recombinant (His)
Artikelnummer: TGM-TMPH-02850-100ug
Description: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
| Schlagworte: | DHOdehase, DHODH, Dihydroorotate oxidase, Dihydroorotate dehydrogenase (quinone), mitochondrial |
| MW: | 44.2 kD |
ab 1.943,00 €
DHODH Protein, Rat, Recombinant (His)
Artikelnummer: TGM-TMPH-03278-100ug
Description: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
| Schlagworte: | Dihydroorotate oxidase, Dihydroorotate dehydrogenase (quinone), mitochondrial, DHOdehase, DHODH |
| MW: | 43.5 kD |
ab 352,00 €
PfDHODH-IN-1
Artikelnummer: TGM-T12438-100mg
Description: PfDHODH-IN-1, an analogue of the active Leflunomide metabolite, exhibits antimalarial activity. Target: Parasite, Dehydrogenase. Smiles: O\C(C1CC1)=C(\C#N)C(=O)Nc1ccc(cc1)C(F)(F)F. References: Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active...
| Anwendung: | DHODH inhibitor |
| CAS | 183945-55-3 |
| MW: | 296.24 D |
ab 110,00 €
ML390
Artikelnummer: TGM-T13774-100mg
Description: ML390 exerts its potent differentiation effect on multiple leukemia models. Target: Dehydrogenase, Others. Smiles: FC(F)(F)Oc1ccc(cc1)C(=O)NCCC(=O)N[C@@H]1CCCc2ccccc12. References: Sykes DB et al. Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia. National...
| Anwendung: | DHODH inhibitor |
| CAS | 2029049-79-2 |
| MW: | 406.4 D |
ab 40,00 €
BAY-2402234
Artikelnummer: TGM-T14501-100mg
Description: BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. Target: Dehydrogenase, DNA/RNA Synthesis. Smiles:...
| Anwendung: | DHODH inhibitor |
| CAS | 2225819-06-5 |
| MW: | 520.84 D |
ab 179,00 €
DSM265
Artikelnummer: TGM-T15173-10mg
Description: DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infections. Target: Parasite, Dehydrogenase. Smiles:...
| Schlagworte: | PfSPZ |
| Anwendung: | Antimalarial agent |
| CAS | 1282041-94-4 |
| MW: | 415.33 D |
ab 31,00 €