Zu "K00213" wurden 27 Artikel gefunden!
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AY 9944
Artikelnummer: TGM-T14362-1mg
Description: AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol Delta7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 also inhibits sterol Delta7-Delta8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3beta-ol[1][2][3]....
| Anwendung: | DHCR7 inhibitor |
| CAS | 366-93-8 |
| MW: | 464.3 D |
ab 37,00 €
7-Dehydrocholesterol
Artikelnummer: TGM-T4923-100mg
Description: 7-Dehydrocholesterol (Provitamin D3) down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts. Target: Endogenous Metabolite. Smiles: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C. References: Lehmann B , Genehr T , Knuschke P , et al....
| Schlagworte: | 7-DHC, Provitamin D3 |
| Anwendung: | Cholesterol precursor |
| CAS | 434-16-2 |
| MW: | 384.64 D |
ab 34,00 €
DHCR7 Protein, Bovine, Recombinant (His)
Artikelnummer: TGM-TMPH-00218-100ug
Description: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. DHCR7 Protein, Bovine, Recombinant (His) is expressed in E. coli...
| Schlagworte: | 7-dehydrocholesterol reductase, DHCR7, 7-DHC reductase, Sterol Delta(7)-reductase |
| MW: | 55.8 kD |
ab 2.161,00 €
7-dehydrocholesterol reductase (DHCR7), bovine, recombinant
Artikelnummer: CSB-CF006844BO.100
Organism: Bos taurus (Bovine). Source: in vitro E.coli expression system. Expression Region: 1-475aa. Protein Length: Full Length. Tag Info: N-terminal 10xHis-tagged. Target Protein Sequence: MAAKSQPSAP KTKSTSGLTN GNAAAQGQWG RAWEVDWFSL ASVIFLLLFA PFIVYYFIMA CDQYGCSLTV PVADLATGRA RLADIWARTP PVTAKAAQIY TAWVTLQVLL...
| Schlagworte: | DHCR7, 7-DHC reductase, Sterol Delta(7)-reductase, 7-dehydrocholesterol reductase, Recombinant Bovine 7-dehydrocholesterol... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli in vitro |
| Ursprungsart: | bovine |
| MW: | 55.8 kD |
ab 1.458,00 €
Anti-DHCR7
Artikelnummer: CSB-PA110763.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: DHCR7. Antigen Species: Human
| Schlagworte: | Anti-D7SR, Anti-DHCR7, Anti-7-DHC reductase, Anti-Sterol reductase SR-2, Anti-Delta7-sterol reductase, Anti-Sterol... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 167,00 €
Anti-DHCR7
Artikelnummer: CSB-PA900410.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: DHCR7. Antigen Species: Human
| Schlagworte: | Anti-D7SR, Anti-DHCR7, Anti-7-DHC reductase, Anti-Sterol reductase SR-2, Anti-Delta7-sterol reductase, Anti-Sterol... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 167,00 €
7-dehydro Cholesterol
Artikelnummer: Cay14612-5
7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3beta-hydroxysterol-Delta7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7...
| Schlagworte: | 7-DHC, NSC 18159, Provitamin D3, Delta7-Cholesterol, cholesta-5,7-dien-3beta-ol |
| Anwendung: | Cholesterol precursor |
| CAS | 434-16-2 |
| MW: | 384.6 D |
ab 53,00 €
AY 9944
Artikelnummer: Cay14611-1
AY 9944 prevents cholesterol biosynthesis by inhibiting the 7-dehydro cholesterol Delta7-reductase (DHCR7) enzyme (IC50 = 13 nM), which interferes with the conversion of 7-dehydro cholesterol (Cay-14612) to cholesterol. Furthermore, by upregulating the expression of DHCR7, AY 9944 can block Hedgehog signaling at the...
| Schlagworte: | trans-N1,N4-bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine, dihydrochloride |
| Anwendung: | DHCR7 inhibitor |
| CAS | 366-93-8 |
| MW: | 464.3 D |
ab 47,00 €
8-dehydro Cholesterol
Artikelnummer: Cay25970-1
8-dehydro Cholesterol (8-DHC) is an isomer of the cholesterol precursor 7-DHC (Cay-14612). It accumulates in tissues and plasma in patients with Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in DHCR7, the gene encoding 3beta-hydroxysterol-Delta7-reductase, and decreased cholesterol levels...
| Schlagworte: | cholesta-5,8-dien-3beta-ol |
| Anwendung: | Smith-Lemli-Opitz syndrome (SLOS) biomarker |
| CAS | 70741-38-7 |
| MW: | 384.6 D |
ab 85,00 €
7-dehydro Cholesterol-d7
Artikelnummer: Cay25969-500
7-dehydro Cholesterol-d7 is intended for use as an internal standard for the quantification of 7-dehydro cholesterol (Cay-14612) by GC- or LC-MS. 7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3beta-hydroxysterol-Delta7-reductase (DHCR7) in the last...
| Schlagworte: | 7-DHC-d7, Provitamin D3-d7, Delta7-Cholesterol-d7, cholesta-5,7-dien-25,26,26,26,27,27,27-d7-3beta-ol |
| Anwendung: | Cholesterol precursor, GC-MS, LC-MS, internal standard |
| CAS | 388622-58-0 |
| MW: | 391.7 D |
ab 259,00 €
Anti-DHCR7
Artikelnummer: ARG56151.100
Protein function: Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC). [The UniProt Consortium]
| Schlagworte: | Anti-D7SR, Anti-DHCR7, EC=1.3.1.21, Anti-7-DHC reductase, Anti-Sterol Delta(7)-reductase, Anti-7-dehydrocholesterol... |
| Anwendung: | ICC, IF, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
616,00 €
Anti-DHCR7
Artikelnummer: A305-321A
Protein function: Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC). [The UniProt Consortium]
| Schlagworte: | Anti-D7SR, Anti-DHCR7, EC=1.3.1.21, Anti-7-DHC reductase, Anti-Sterol Delta(7)-reductase, Anti-Putative sterol reductase... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €