Zu "K00031" wurden 166 Artikel gefunden!
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(2R)-Octyl-alpha-hydroxyglutarate
Artikelnummer: Cay16366-10
alpha-Hydroxyglutaric acid (2-HG, Cay-16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2,...
| Schlagworte: | (2R)-Octyl-2-HG, 2R-hydroxy-pentanedioic acid, 1-octyl ester |
| CAS | 1391194-67-4 |
| MW: | 260.3 D |
ab 39,00 €
Mutant IDH1-IN-1
Artikelnummer: TGM-T2043-100mg
Description: Mutant IDH1-IN-1 is a potent inhibitor of the mutant IDH1 R132 h, exhibiting an IC50 of less than 0.1 µM. Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH). Smiles: Cc1ccccc1C(N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCCC1. References: Janeta Popovici-Muller, et al. Patent WO2012009678 A1.
| Schlagworte: | IDH1-IN-1 |
| Anwendung: | IDH1 R132H inhibitor |
| CAS | 1355326-21-4 |
| MW: | 498.59 D |
ab 63,00 €
Ivosidenib
Artikelnummer: TGM-T3617-100mg
Description: Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular...
| Schlagworte: | AG-120 |
| Anwendung: | Targets isocitrate dehydrogenase [EC:1.1.1.42] (IDH1, IDH2, icd) |
| CAS | 1448347-49-6 |
| MW: | 582.96 D |
ab 42,00 €
ML-309 (hydrochloride)
Artikelnummer: TGM-T38004-10mg
Description: ML-309 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively). ML-309 reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells (EC50 = 55 nM). Target: Others. Smiles:...
| Anwendung: | IDH1 (R132H mutant ) inhibitor |
| CAS | 1355327-02-4 |
| MW: | 521.03 D |
ab 96,00 €
Mutant IDH1-IN-6
Artikelnummer: TGM-T39716-5mg
Description: Mutant IDH1-IN-6 is an orally active compound that effectively inhibits mutant isocitrate dehydrogenase (IDH) enzymes. It demonstrates potency and selectivity, with IC50 values of 6.27, 3.71, 36.9, and 11.5 nM for IDH1 R132H, IDH1 R132C, IDH2 R140Q, and IDH2 R172K mutants, respectively. Notably, Mutant...
| Schlagworte: | Mutant IDH1-IN-6 |
| Anwendung: | Targets isocitrate dehydrogenase [EC:1.1.1.42] (IDH1, IDH2, icd) |
| CAS | 2230263-60-0 |
| MW: | 504.635 D |
951,00 €
IDH1 Inhibitor 5
Artikelnummer: TGM-T62725-100mg
Description: IDH1 Inhibitor 5 (compound 2) is an IDH1 (isocitrate dehydrogenase 1) inhibitor with an IC50 of 64.4 nM for MOG cells and an IC50 of 34.9 nM for wild-type IDH1 glioma cells expressing exogenous mutant IDH1 R132H protein. Target: Others. Smiles:...
| Anwendung: | IDH1 inhibitor |
| CAS | 1940128-37-9 |
| MW: | 450.57 D |
ab 2.100,00 €
IDH1 Inhibitor 7
Artikelnummer: TGM-T72705-100mg
Description: IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC 50 of less than 100 nM . Target: Others. Smiles: [C@@H](C)(C)[C@@H]1N(C2=NC(N[C@@H](C)C3=CN(C=N3)C4=CC=C(C(F)(F)F)C=C4)=NC=C2)C(=O)NC1
| Anwendung: | IDH1 inhibitor |
| CAS | 2135309-56-5 |
| MW: | 459.47 D |
ab 1.393,00 €
DS-1001b
Artikelnummer: TGM-T7741-100mg
Description: DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1). Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH). Smiles: CC(C)(C)N.Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12. References: Yoshiki A , Yohei M , Toshihiko W , et al. ACT-14 A FIRST-IN-HUMAN STUDY OF...
| Anwendung: | Mutant IDH1 inhibitor |
| CAS | 1898207-64-1 |
| MW: | 608.92 D |
ab 32,00 €
Vorasidenib
Artikelnummer: TGM-T7307-100mg
Description: Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH, IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively). Target: Isocitrate Dehydrogenase (IDH). Smiles: C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F. References: Zakkula A, Dittakavi S, Maniyar...
| Schlagworte: | AG-881, PVM/MA |
| Anwendung: | Targets isocitrate dehydrogenase [EC:1.1.1.42] (IDH1, IDH2, icd) |
| CAS | 1644545-52-7 |
| MW: | 414.74 D |
ab 48,00 €
Isocitrate dehydrogenase/IDH1 Protein, Human, Recombinant...
Artikelnummer: TGM-TMPY-02413-1mg
Description: Isocitrate dehydrogenase/IDH1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 48 kDa and the accession number is O75874.
| Schlagworte: | HEL-S-26, IDCD, HEL-216, IDP, PICD, isocitrate dehydrogenase 1 (NADP+), soluble, IDH, IDPC |
| MW: | 48 kD |
ab 686,00 €
BAY-1436032
Artikelnummer: TGM-TQ0042-10mg
Description: BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1). Target: Isocitrate Dehydrogenase (IDH), Dehydrogenase. Smiles: C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)ccc12. References: Chaturvedi A, et al. Pan-mutant-IDH1...
| Anwendung: | Mutant IDH1 inhibitor |
| CAS | 1803274-65-8 |
| MW: | 489.53 D |
ab 32,00 €
AGI-6780
Artikelnummer: TGM-T1809-100mg
Description: AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant. Target: Isocitrate Dehydrogenase (IDH), Dehydrogenase. Smiles: FC(F)(F)c1cccc(NC(=O)Nc2cc(ccc2-c2ccsc2)S(=O)(=O)NC2CC2)c1. References: Wang F, et al. Science. 2013, 340(6132), 622-666.
| Anwendung: | Mutant IDH2 inhibitor |
| CAS | 1432660-47-3 |
| MW: | 481.51 D |
ab 32,00 €