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Zu "K00021" wurden 77 Artikel gefunden!
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Artikelnummer: ELK-ELK0431.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse HMGCR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse HMGCR. Next,...
Schlagworte: | Hmgcr, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
ab 293,00 €
Artikelnummer: CDX-P0933-M050
Pravastatin is a water-soluble, orally effective, competitive inhibitor of Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (Ki = 2.3nM), the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the statin class of cholesterol-lowering/regulating compounds. Pravastatin potently blocks...
Schlagworte: | Eptastatin sodium salt, 3beta-Hydroxycompactin, Mevalothin |
Anwendung: | HMG-CoA reductase inhibitor |
MW: | 446,51 D |
87,00 €
Artikelnummer: ELK-ELK6333.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat HMGCR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat HMGCR. Next,...
Schlagworte: | Hmgcr, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Anwendung: | ELISA |
Spezies-Reaktivität: | rat |
ab 365,00 €
Artikelnummer: ELK-ELK5163.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human HMGCR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human HMGCR. Next,...
Schlagworte: | HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: LKT-R5974.25
Statin, HMG-CoA reductase inhibitor, potential NADPH oxidase and PKC inhibitor.
Schlagworte: | (S-((R*,S*-(E)))- 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2- (methyl(methylsulfonyl) amino)-5-pyrimidinyl)-3,5-dihydroxy-... |
Anwendung: | HMGCoA reductase inhibitor |
CAS | 147098-20-2 |
MW: | 1001,14 D |
ab 223,00 €
Artikelnummer: Cay10010338-50
Lovastatin is a fungal metabolite that has been found in A. terreus and an inhibitor of HMG-CoA reductase (Ki = 1.4 nM). It is also a prodrug form of the HMG-CoA reductase inhibitor lovastatin hydroxy acid (Cay-10010339). Lovastatin (8 mg/kg per day) reduces plasma cholesterol levels in dogs. It suppresses...
Schlagworte: | 2S-methyl-butanoic acid,... |
Anwendung: | NF-kappaB activation inhibitor |
CAS | 75330-75-5 |
MW: | 404.5 D |
ab 35,00 €
Artikelnummer: Cay10010344-5
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Schlagworte: | MK-733,... |
Anwendung: | HMG-CoA reductase inhibitor |
CAS | 79902-63-9 |
MW: | 418.6 D |
ab 43,00 €
Artikelnummer: Cay10493-50
Atorvastatin is an inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol synthesis, that has IC50 values of 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively. Formulations containing atorvastatin have been used in the treatment of...
Schlagworte: | 2-(4-fluorophenyl)-betaR,deltaR-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic... |
Anwendung: | HMGCR inhibitor |
CAS | 357164-38-6 |
MW: | 577.7 D |
ab 43,00 €
Artikelnummer: Cay10010334-10
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
Schlagworte: | 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid |
Anwendung: | HMG-CoA reductase inhibitor |
CAS | 93957-54-1 |
MW: | 411.5 D |
ab 54,00 €
Artikelnummer: Cay12029-10
Rosuvastatin is an inhibitor of HMG-CoA reductase (IC50 = 5 nM). It inhibits cholesterol synthesis in isolated rat hepatocytes with an IC50 value of 0.16 nM. Rosuvastatin (10 mg/kg) reduces plasma total cholesterol, triglyceride, LDL-C, and oxidized LDL-C levels in Ldlr-/- mice fed a high-fat diet. It decreases the...
Schlagworte: | ZD 4522,... |
Anwendung: | HMG-CoA reductase inhibitor |
CAS | 287714-41-4 |
MW: | 481.5 D |
ab 76,00 €
Artikelnummer: Cay18115-10
SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity by enhancing the degradation of HMG-CoA reductase in various animal models. SR-12813 is also a high affinity ligand for human and rabbit pregnane X receptors (Kd = 41 nM, EC50 = 137 nM for hPXR in vitro) and can induce cytochrome P450...
Schlagworte: | GW 485801, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid P,P,P',P'-tetraethyl ester |
Anwendung: | HMG-CoA reductase degradation enhancer, Pregnane X receptor ligand |
CAS | 126411-39-0 |
MW: | 504.5 D |
ab 115,00 €
Artikelnummer: LKT-F4482.10
An anticholesterol agent. It is a HMG-CoA reductase inhibitor and antioxidant.
Schlagworte: | Fluindostatin, XU-62-320 |
Anwendung: | HMG-CoA reductase inhibitor |
CAS | 93957-55-2 |
MW: | 433,45 D |
ab 67,00 €