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Sotuletinib
Artikelnummer: TGM-T6119-100mg
Description: Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective against its closest receptor tyrosine kinase homologs. Target: c-Fms, CSF-1R. Smiles: CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1. References: Pyonteck SM, et al. Nat Med. 2013,...
| Schlagworte: | BLZ945 |
| Anwendung: | Anticancer compound, CSF-1R / c-Fms inhibitor |
| CAS | 953769-46-5 |
| MW: | 398.48 D |
ab 32,00 €
BLZ-945
Artikelnummer: Cay19626-1
BLZ-945 is a selective inhibitor of the colony stimulating factor 1 receptor (CSF1R) with an IC50 value of 1 nM. It is more than 1,000-fold selective against its closest receptor tyrosine kinase homologs. It has been shown to inhibit CSF1-dependent proliferation with an EC50 value of 67 nM in bone marrow-derived...
| Schlagworte: | 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-2-pyridinecarboxamide |
| Anwendung: | Anticancer compound, CSF-1R / c-Fms inhibitor |
| CAS | 953769-46-5 |
| MW: | 398.5 D |
ab 34,00 €
BLZ-945
Artikelnummer: SYN-1197-M001
Soluble in DMSO. BLZ945 is an orally active, potent and selective CSF-1R inhibitor, which inhibits CSF-1R activity with an IC(50) of 1nM and is more than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and Platelet-derived Growth Factor Receptor beta (PDGFRbeta ) as well as more than...
| Schlagworte: | BLZ945 |
| Anwendung: | CSF1R / c-FMS inhibitor |
| CAS | 953769-46-5 |
| MW: | 398,5 D |
ab 211,00 €
BLZ-945
Artikelnummer: AG-CR1-3609-M001
Pale yellow solid. Soluble in DMSO. Slightly soluble in ethanol. Insoluble in water. Anticancer compound, Orally active, potent and selective colony stimulating factor 1 receptor (CSF-1R, c-Fms) inhibitor, More than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and platelet-derived...
| Schlagworte: | BLZ945 |
| Anwendung: | Anticancer compound, CSF-1R / c-Fms inhibitor |
| CAS | 953769-46-5 |
| MW: | 398,5 D |
ab 44,00 €
BLZ-945
Artikelnummer: LKT-B4796.1
CSF-1R Inhibitor.
| Schlagworte: | BLZ945 |
| Anwendung: | CSF-1R Inhibitor |
| CAS | 953769-46-5 |
| MW: | 398.48 D |
ab 140,00 €
