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JNJ-38158471
Artikelnummer: Cay41361-10
JNJ-38158471 is an inhibitor of VEGFR2 (IC50 = 42 nM). It is selective for VEGFR2 over the PDGFR family kinases CSF-1 receptor tyrosine kinase (FMS), PDGFRalpha, FMS-related tyrosine kinase 3 (FLT3), and KIT (IC50s = 624, 1,109, 4,810, and 511 nM, respectively) and VEGFR family kinases VEGFR1 and VEGFR3 (IC50s =...
| Schlagworte: | N-[4-[[6-amino-5-[(methoxyimino)methyl]-4-pyrimidinyl]oxy]-2-chlorophenyl]-N'-ethyl-urea |
| Anwendung: | VEGFR2 inhibitor |
| CAS | 951151-97-6 |
| MW: | 364.8 D |
ab 272,00 €
JNJ-38158471
Artikelnummer: SYN-1133-M001
Soluble in DMSO. JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with an IC(50) of 40nM. It also inhibits closely related tyrosine kinases such as Ret (IC(50) of 180nM) and Kit (C50 of 500nM). It has no significant activity (>1µM) against VEGFR-1 and VEGFR-3. Target: VEGFR-2 ,...
| Schlagworte: | JNJ38158471 |
| Anwendung: | VEGFR-2 inhibitor |
| CAS | 951151-97-6 |
| MW: | 364,8 D |
ab 293,00 €
JNJ-38158471
Artikelnummer: TGM-T22349-100mg
Description: JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM. Target: c-RET, VEGFR, c-Kit. Smiles: CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N\OC)cc1Cl
| Schlagworte: | CS-2660 |
| Anwendung: | VEGFR-2 inhibitor |
| CAS | 951151-97-6 |
| MW: | 364.79 D |
ab 48,00 €
