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Lotamilast
Artikelnummer: TGM-T3987-100mg
Description: Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis. Target: PDE. Smiles: CNc1nc(-c2cccc(NC(=O)c3ccc(cc3)C(=O)OC)c2)c2cc(OC)c(OC)cc2n1. References: Nemoto O., et al. Effect of topical phosphodiesterase 4 inhibitor E6005 on...
| Schlagworte: | RVT-501, E6005 |
| Anwendung: | Targets cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] (PDE4) |
| CAS | 947620-48-6 |
| MW: | 472.49 D |
ab 30,00 €
E6005
Artikelnummer: Cay30203-1
E6005 is an inhibitor of phosphodiesterase 4 (PDE4, IC50 = 2.8 nM). It is selective for PDE4 over PDE1, PDE2, PDE3, and PDE5 with only 46.1, 51.6, 69.4, and 57.4% inhibition, respectively, at 30 µM. It inhibits the production of various cytokines in isolated human lymphocytes and monocytes (IC50s = 0.49-3.1 nM)....
| Schlagworte: | RVT-501, 4-[[[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]amino]carbonyl]-benzoic acid, methyl ester |
| Anwendung: | PDE4 inhibitor |
| CAS | 947620-48-6 |
| MW: | 472.5 D |
ab 49,00 €
