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Ro 5126766
Artikelnummer: Cay29197-1
Ro 5126766 is a dual inhibitor of MEK1 (IC50 = 160 nM) and Raf kinases (IC50s = 56, 19, and 8.2 nM for C-RAF, B-RAF, and B-RAFV600E, respectively). It is selective for these kinases over a panel of 254 additional kinases at 10 µM. Ro 5126766 (1 µM) decreases MEK and ERK phosphorylation in a panel of seven cancer...
| Schlagworte: | CH5126766, N-[3-fluoro-4-[[4-methyl-2-oxo-7-(2-pyrimidinyloxy)-2H-1-benzopyran-3-yl]methyl]-2-pyridinyl]-N'-methyl-sulfamide |
| Anwendung: | MEK1 / RAF kinases dual inhibitor |
| CAS | 946128-88-7 |
| MW: | 471.5 D |
ab 100,00 €
