Zu "944396-07-0" wurden 4 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Buparlisib
Artikelnummer: TGM-T1827-100mg
Description: Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110alpha, p110beta, and p110delta). Target: Apoptosis, PI3K. Smiles: Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F. References: Burger MT, et al. Identification of NVP-BKM120 as...
| Schlagworte: | BKM120, NVP-BKM120 |
| Anwendung: | Targets phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta |
| CAS | 944396-07-0 |
| MW: | 410.39 D |
ab 57,00 €
NVP-BKM120
Artikelnummer: Cay11587-25
NVP-BKM120 is an orally bioavailable inhibitor of the class I PI3K isoforms p110alpha (IC50 = 52 nM) and p110beta (IC50 = 166 nM). It is selective for these isoforms over the class III PI3K Vps34 (IC50 = 2,410 nM), the mammalian target of rapamycin (mTOR, IC50 = 2,866 nM), PI4Kbeta (IC50 = >25,000 nM), and a variety...
| Schlagworte: | Buparlisib, 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine |
| Anwendung: | Class I PI3K isoform p110alpha inhibitor |
| CAS | 944396-07-0 |
| MW: | 410.4 D |
ab 36,00 €
BKM120
Artikelnummer: LKT-B4248.1
BKM120 is an inhibitor of PI3K that is currently in clinical trials as a potential treatment for brain metastases of HER2+ breast cancer and other solid tumors. BKM120 exhibits anticancer chemotherapeutic activity, inducing G2/M phase cell cycle arrest, polyploidy, and apoptosis in glioblastoma cells. Additionally,...
| Schlagworte: | Buparlisib, NVP-BKM120 |
| Anwendung: | PI3K p110 inhibitor |
| CAS | 944396-07-0 |
| MW: | 410.39 D |
ab 114,00 €
BKM-120
Artikelnummer: SYN-1200-M005
Soluble in DMSO or ethanol. NVP-BKM120 is a potent, selective, orally bioavailable Class I PI3Kalpha Inhibitor with IC(50) of 20nM, currently in Phase II clinical trials for the treatment of cancer. It exhibits lower potency against class III and class IV PI3Ks Target: PI3K , Kinase Group: Lipid Kinase ,...
| Schlagworte: | NVP-BKM120 |
| Anwendung: | PI3K inhibitor |
| CAS | 944396-07-0 |
| MW: | 410,4 D |
ab 92,00 €
