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Ruxolitinib
Artikelnummer: Cay11609-1
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative...
| Schlagworte: | INCB 018424, betaR-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile |
| Anwendung: | Jak1/2 inhibitor |
| CAS | 941678-49-5 |
| MW: | 306.4 D |
ab 32,00 €
COVID-19 Forschung
Ruxolitinib
Artikelnummer: AG-CR1-3624-M005
White to off-white solid. Soluble in DMSO or ethanol. Insoluble in water. Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50 = 322nM), Affects DC...
| Schlagworte: | INCB018424, INC 424 |
| Anwendung: | JAK1 inhibitor, JAK2 inhibitor |
| CAS | 941678-49-5 |
| MW: | 306,4 D |
ab 72,00 €
Ruxolitinib, Free Base (INCB018424, INCB18424, NCB018424,...
Artikelnummer: LC-R-6600_100mg
Soluble in DMSO at 28 mg/mL, soluble in ethanol at 15 mg/mL with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 25-50 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
| Schlagworte: | INCB 018424, betaR-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile |
| Anwendung: | Jak1/2 inhibitor |
| CAS | 941678-49-5 |
| MW: | 306,37 D |
ab 204,00 €
INCB018424
Artikelnummer: LKT-I5210.5
JAK1/2 inhibitor.
| Schlagworte: | Ruxolitinib |
| Anwendung: | Janus kinase 1 (JAK1) inhibitor, janus kinase 2 (JAK2) inhibitor |
| CAS | 941678-49-5 |
| MW: | 306.37 D |
ab 129,00 €
