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Rebeccamycin
Artikelnummer: BVT-0139-C250
Antibiotic, Weak topoisomerase I (Topo I) inhibitor, Structurally similar to staurosporine, Does not show any inhibitory activity against protein kinases, Shows significant antitumor properties in vitro (IC50 = 480 nM against mouse B16 melanoma cells and IC50 = 500 nM against P388 leukemia cells). Isolated from...
| Schlagworte: | NSC 359079, BRN 4732638 |
| Anwendung: | Topoisomerase I (Topo I) inhibitor |
| CAS | 93908-02-2 |
| MW: | 570,4 D |
ab 95,00 €
Rebeccamycin
Artikelnummer: Cay17914-2.5
Rebeccamycin is an indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I. It is cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s range from 0.4-98 µM), producing single-strand breaks in the DNA of these...
| Schlagworte: | BRN 4732638, NSC 359079,... |
| Anwendung: | Antibiotic, weak DNA topoisomerase I inhibitor |
| CAS | 93908-02-2 |
| MW: | 570.4 D |
ab 238,00 €
