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Ku-0063794
Artikelnummer: Cay13597-5
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival. Ku-0063794 is a cell-permeable, selective dual inhibitor of mTORC1 and...
| Schlagworte: | rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-benzenemethanol |
| Anwendung: | TORC1/2 inhibitor |
| CAS | 938440-64-3 |
| MW: | 465.5 D |
ab 98,00 €
KU-0063794
Artikelnummer: SYN-1050-M005
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. KU0063794 is a highly specific inhibitor of the mammalian target of rapamycin (mTOR). It inhibits both mTORC1 and mTORC2 with an IC(50) of approximately 10nM. Target: mTOR , Kinase Group: Atypical (PIKK) , Substrate: Serine-Threonine
| Schlagworte: | KU0063794 |
| Anwendung: | mTOR inhibitor |
| CAS | 938440-64-3 |
| MW: | 465,6 D |
ab 92,00 €
KU-0063794
Artikelnummer: TGM-T2475-100mg
Description: KU-0063794 is a potent and highly specific dual inhibitor of mTORC1 and mTORC2. Target: mTOR. Smiles: COc1ccc(cc1CO)-c1ccc2c(nc(nc2n1)N1C[C@H](C)O[C@H](C)C1)N1CCOCC1. References: García-Martínez JM, et al. Biochem J, 2009, 421(1), 29
| Anwendung: | TORC1/2 inhibitor |
| CAS | 938440-64-3 |
| MW: | 465.54 D |
ab 52,00 €
