Zu "936727-05-8" wurden 2 Artikel gefunden!
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VX-809
Artikelnummer: Cay22196-5
VX-809 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation carried by 90% of cystic fibrosis patients. It enhances F508del-CFTR protein maturation and restores chloride transport function in FRT cells...
| Schlagworte: | VRT-826809, 3-[6-[[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]-benzoic acid |
| Anwendung: | CFTR corrector |
| CAS | 936727-05-8 |
| MW: | 452.4 D |
ab 52,00 €
Lumacaftor
Artikelnummer: TGM-T2595-100mg
Description: Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM). Target: CFTR, Autophagy. Smiles: Cc1ccc(NC(=O)C2(CC2)c2ccc3OC(F)(F)Oc3c2)nc1-c1cccc(c1)C(O)=O. References: Van Goor F, et al....
| Schlagworte: | VX-809, VRT 826809 |
| Anwendung: | Targets cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6] (CFTR, ABCC7) |
| CAS | 936727-05-8 |
| MW: | 452.41 D |
ab 43,00 €
