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Motolimod
Artikelnummer: TGM-T6898-100mg
Description: Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7. Target: TLR. Smiles: CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1ccc(cc1)C(=O)N1CCCC1. References: Lu H, et al. Clin Cancer Res. 2012, 18(2), 499-509.
| Schlagworte: | VTX-2337, VTX-378 |
| Anwendung: | Targets toll-like receptor 8 (TLR8, CD288) |
| CAS | 926927-61-9 |
| MW: | 458.6 D |
ab 51,00 €
Motolimod
Artikelnummer: Cay22952-5
Motolimod is an agonist of toll-like receptor 8 (TLR8). It increases the production of TNF-alpha and IL-12 in human peripheral blood mononuclear cells (PBMCs, EC50s = 140 and 120 nM, respectively), monocytes, and myeloid dendritic cells. Motolimod also increases IFN-gamma production in natural killer (NK) cells and...
| Schlagworte: | VTX-2337, 2-amino-N,N-dipropyl-8-[4-(1-pyrrolidinylcarbonyl)phenyl]-3H-1-benzazepine-4-carboxamide |
| Anwendung: | Toll-like receptor 8 (TLR8) agonist |
| CAS | 926927-61-9 |
| MW: | 458.6 D |
ab 44,00 €
