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PLX4720
Artikelnummer: Cay15142-1
The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and thyroid cancer but is poorly targeted by many inhibitors of...
| Schlagworte: | Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Anwendung: | BRAFV600E inhibitor |
| CAS | 918505-84-7 |
| MW: | 413.8 D |
ab 61,00 €
PLX4720
Artikelnummer: LKT-P4492.25
PLX-4720 is a potent and selective inhibitor of b-Raf(V600E) and c-Raf-1(Y340D/Y431D)
| Schlagworte: | N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide |
| Anwendung: | B-Raf (V600E) / c-Raf (Y340D/Y431D) inhibitor |
| CAS | 918505-84-7 |
| MW: | 413.83 D |
ab 223,00 €
PLX4720
Artikelnummer: AG-CR1-3577-M005
Synthetic. Potent and selective cell permeable B-Raf (V600E) and c-Raf-1 (Y340D/Y341D) inhibitor. Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-Raf(V600E)-bearing tumor cell lines.
| Schlagworte: | N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide |
| Anwendung: | B-Raf (V600E) / c-Raf-1 (Y340D/Y341D) inhibitor |
| CAS | 918505-84-7 |
| MW: | 413,8 D |
ab 94,00 €
PLX-4720
Artikelnummer: TGM-T2473-100mg
Description: PLX-4720, a potent and selective inhibitor of B-Raf (V600E) with an IC50 of 13 nM, is equally effective against c-Raf-1 (Y340D and Y341D mutations). Target: Raf. Smiles: CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F. References: Tsai J, et al. Discovery of a selective inhibitor of oncogenic B-Raf...
| Schlagworte: | PLX4720 |
| Anwendung: | B-Raf (V600E) / c-Raf-1 (Y340D/Y341D) inhibitor |
| CAS | 918505-84-7 |
| MW: | 413.83 D |
ab 33,00 €
