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MK-2461
Artikelnummer: TGM-T6094-100mg
Description: MK-2461 is a novel inhibitor that targets multiple proteins and competitively binds to ATP sites, specifically inhibiting the activated c-Met protein with an average inhibitory concentration (IC50) of 2.5 nM. Target: c-Met/HGFR. Smiles: CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1....
| Schlagworte: | MK2461 |
| Anwendung: | c-MET inhibitor |
| CAS | 917879-39-1 |
| MW: | 495.55 D |
ab 48,00 €
MK-2461
Artikelnummer: LKT-M4004.1
MK-2461 is an inhibitor of MET that also shows inhibition of FGFR and PDGFR. In animal models of glioblastoma and gastric cancer, MK-2461 exhibits anticancer chemotherapeutic activity, decreasing tumor growth and size.
| Schlagworte: | MK2461 |
| Anwendung: | MET / FGFR / PDGFR inhibitor |
| CAS | 917879-39-1 |
| MW: | 495.55 D |
ab 159,00 €
MK-2461
Artikelnummer: SYN-1149-M001
Soluble in DMSO or ethanol. MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met kinases (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC(50) values of 0.4 to 2.5nM.
| Schlagworte: | MK2461 |
| Anwendung: | Activated MET inhibitor |
| CAS | 917879-39-1 |
| MW: | 495,6 D |
ab 254,00 €
MK-2461
Artikelnummer: Cay32964-1
MK-2461 is an inhibitor of wild-type and mutant forms of c-MET (IC50s = 0.4-2 nM). It is selective for c-MET over a panel of 13 additional kinases (IC50s = 22-7,800 nM) but does inhibit Ron and FLT1 (IC50s = 7 and 10 nM, respectively). MK-2461 also inhibits autophosphorylation of FGFR2 and PDGFRalpha in KATO III...
| Schlagworte: | N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]... |
| Anwendung: | c-MET inhibitor |
| CAS | 917879-39-1 |
| MW: | 495.6 D |
ab 250,00 €
