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GS143
Artikelnummer: TGM-T25465-100mg
Description: GS143 is a selective IkappaBalpha ubiquitination inhibitor with an IC50 of 5.2 µM for SCFbetaTrCP1-mediated IkappaBalpha ubiquitylation. It suppresses NF-kappaB activation and transcription of target genes without inhibiting proteasome activity. GS143 has anti-asthm[atic] properties. Target: NF-kappaB,...
| Schlagworte: | GS 143, GS-143 |
| Anwendung: | IkappaBalpha ubiquitylation inhibitor |
| CAS | 916232-21-8 |
| MW: | 466.46 D |
ab 38,00 €
GS-143
Artikelnummer: Cay26138-10
GS-143 is an inhibitor of IkappaBalpha ubiquitylation. It inhibits ubiquitylation of phosphorylated IkappaBalpha mediated by the SCFbetaTrCP1 E3 ubiquitin ligase complex in vitro (IC50 = 5.2 µM) and reduces TNF-alpha-induced degradation of phosphorylated IkappaBalpha, but not beta-catenin, another SCFbetaTrCP1...
| Schlagworte: | 4-[4-[[5-(2-fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]-benzoic acid |
| Anwendung: | IkappaBalpha ubiquitylation inhibitor |
| CAS | 916232-21-8 |
| MW: | 466.5 D |
ab 142,00 €
