Zu "905586-69-8" wurden 2 Artikel gefunden!
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AZ 960
Artikelnummer: Cay16731-1
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F)....
| Schlagworte: | 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile |
| Anwendung: | JAK2 inhibitor |
| CAS | 905586-69-8 |
| MW: | 354.4 D |
ab 158,00 €
AZ 960
Artikelnummer: AG-CR1-3752-M001
AZ-960 is a potent, selective and ATP-competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45nM in vitro (3-fold selective over JAK3) and induces growth arrest and apoptosis in adult T cell leukemia (ATL) cells. Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for...
| Schlagworte: | AZ960, AZ-960 |
| Anwendung: | JAK2 inhibitor |
| CAS | 905586-69-8 |
| MW: | 354.4 D |
ab 77,00 €
