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PFI-4
Artikelnummer: TGM-T1973-100mg
Description: PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor. Target: Epigenetic Reader Domain. Smiles: COc1ccccc1C(=O)Nc1cc2n(C)c(=O)n(C)c2cc1N1CCCC1. References: Demont EH, et al. ACS Med Chem Lett. 2014, 5(11), 1190-1195.
| Schlagworte: | PFI4 |
| Anwendung: | BRPF1 bromodomain probe, tri-acetylated histone 4 binding inhibitor |
| CAS | 900305-37-5 |
| MW: | 380.44 D |
ab 40,00 €
PFI-4
Artikelnummer: Cay17663-1
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1, aka BR140 or Peregrin, is important for maintaining Hox gene expression and the development of multiple...
| Schlagworte: | N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy benzamide |
| Anwendung: | BRPF1 bromodomain probe, tri-acetylated histone 4 binding inhibitor |
| CAS | 900305-37-5 |
| MW: | 380.4 D |
ab 61,00 €
PFI-4
Artikelnummer: SYN-3047-M001
Potent and selective BRPF1 bromodomain inhibitor, with an IC50 of 80nM. PFI-4 exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. PFI-4 specifically binds to the bromodomain of BRPF1 (Kd = 13nM), inhibiting binding to tri-acetylated histone 4 (residues...
| Schlagworte: | N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy benzamide |
| Anwendung: | Potent,selective BRPF1 bromodomain inhibitor |
| CAS | 900305-37-5 |
| MW: | 380.5 D |
ab 77,00 €
AZ9482
Artikelnummer: SYN-3046-M100
AZ9482 is a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18nM). AZ9482 also showed a 3nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with...
| Schlagworte: | 2-(4-(3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile |
| Anwendung: | Potent, selective PARP inhibitor |
| CAS | 900305-37-5 |
| MW: | 450.5 D |
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