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Tanzisertib
Artikelnummer: TGM-T14895-100mg
Description: Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity. Target: JNK. Smiles: Cl.OC1CCC(CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CCOC3)c2n1. References: Plantevin Krenitsky V, et al. Discovery of CC-930, an orally active...
| Schlagworte: | CC-930 |
| Anwendung: | Targets mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24] (JNK) |
| CAS | 899805-25-5 |
| MW: | 448.44 D |
ab 37,00 €
CC-930
Artikelnummer: Cay22466-1
CC-930 is an orally bioavailable and potent inhibitor of JNKs (IC50s = 61, 7, and 6 nM for JNK1, JNK2, and JNK3, respectively). It is selective for MAP kinases over a panel of 240 kinases, showing greater than 50% inhibition at only one non-MAP kinase target, EGFR (IC50 = 380 nM). Within the MAPK family, it is...
| Schlagworte: | Tanzisertib, trans-4-[[9-[(3S)-tetrahydro-3-furanyl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl]amino]-cyclohexanol |
| Anwendung: | JNK inhibitor |
| CAS | 899805-25-5 |
| MW: | 448.4 D |
ab 49,00 €
