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Mardepodect
Artikelnummer: TGM-T16499-100mg
Description: Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM and over 1000-fold selectivity over PDE. It is potentially useful for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is highly expressed in striatal medium spiny neurons of...
| Schlagworte: | PF-2545920 |
| Anwendung: | Targets cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 (PDE10) |
| CAS | 898562-94-2 |
| MW: | 392.45 D |
ab 37,00 €
PF-2545920
Artikelnummer: Cay18266-1
PF-2545920 is a potent inhibitor of phosphodiesterase 10A (PDE10A, IC50 = 1.26 nM for the human recombinant enzyme). It is selective for PDE10A over other PDEs with IC50 values ranging from 1.7 to >10 µM. In vivo, PF-2545920 (0.1-3 mg/kg, i.p.) increases cAMP and cGMP production as well as phosphorylation of CREB...
| Schlagworte: | 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-quinoline |
| Anwendung: | PDE10A inhibitor |
| CAS | 898562-94-2 |
| MW: | 392.5 D |
ab 78,00 €
PF-2545920
Artikelnummer: AG-CR1-3636-M001
Solid. Soluble in DMSO or ethanol. Insoluble in water. Potent and selective phosphodiesterase 10A (PDE10A) inhibitor (IC50=1.26nM) in vitro and in vivo. PDE10A is a cGMP and cAMP degrading PDE isozyme with neurological importance and was shown to be implicated in the regulation of energy homeostasis. Inhibition of...
| Schlagworte: | 2-(4-(1-Methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)-phenoxymethyl)quinoline, MP-10 |
| Anwendung: | PDE10A inhibitor |
| CAS | 898562-94-2 |
| MW: | 392,5 D |
ab 55,00 €
