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BMH-21
Artikelnummer: TGM-T1767-100mg
Description: BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX. Target: DNA/RNA Synthesis. Smiles: CN(C)CCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O. References: Peltonen K, et al. Cancer Cell. 2014, 25(1), 77-90.
| Schlagworte: | BMH21 |
| CAS | 896705-16-1 |
| MW: | 360.41 D |
ab 37,00 €
BMH-21
Artikelnummer: Cay22282-5
BMH-21 is an inhibitor of RNA polymerase I. It binds to GC-rich sequences in DNA and ribosomal DNA (rDNA) and inhibits RNA polymerase I transcription in vitro. It inhibits expression of the 47S rRNA transcript (IC50 = 60 nM), disrupts the structure of the nucleolus, and leads to removal of the RNA polymerase complex...
| Schlagworte: | N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide |
| Anwendung: | RNA polymerase 1 inhibitor |
| CAS | 896705-16-1 |
| MW: | 360.4 D |
ab 85,00 €
