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BGG463
Artikelnummer: Cay41146-1
BGG463 is a derivative of BBT594, an inhibitor of the fusion protein Bcr-AblT315I.Formal Name: 6-[[6-(acetylamino)-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide. CAS Number: 890129-26-7. Synonyms: K03859, NVP-BGG463. Molecular Formula: C30H29F3N6O3....
| Schlagworte: | K03859, NVP-BGG463,... |
| Anwendung: | BBT594 (Bcr-Abl.T315I inhibitor) derivative |
| CAS | 890129-26-7 |
| MW: | 578.6 D |
ab 47,00 €
BBT594
Artikelnummer: SYN-1225-M100
BBT594 (NVP-BBT594) is a potent and selective inhibitor of RET and JAK2. BBT594 impairs "glial-derived neurotrophic factor" (GDNF)-RET signaling and GDNF-dependent growth in specific in vitro models. Direct inhibition of GDNF-RET signaling by BBT594 in ER+ breast cancer cells enhances the sensitivity to aromatase...
| Schlagworte: | BBT-594 |
| Anwendung: | Potent, selective RET / JAK2 inhibitor |
| CAS | 890129-26-7 |
| MW: | 569.6 D |
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BGG463
Artikelnummer: SYN-1226-M001
BGG463 (NVP-BGG463) was generated by a rational 'hybrid design' approach. Like Imatinib, BGG463 disrupts the assembly of the hydrophobic spine, a characteristic feature of the active state of several kinases, thereby locking the kinase in an inactive 'DFG-out' conformation. BGG463 can inhibit c-ABL-T334I, BCR-ABL...
| Schlagworte: | BGG-463 |
| Anwendung: | Kinase active state disruptor |
| CAS | 890129-26-7 |
| MW: | 578.6 D |
ab 250,00 €
