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Ripasudil (hydrochloride hydrate)
Artikelnummer: Cay19920-5
Ripasudil is an inhibitor of Rho-associated kinase 1 (ROCK1) and ROCK2 (IC50s = 51 and 19 nM, respectively). It is selective for ROCK1 and ROCK2 over protein kinase A catalytic subunit alpha (PKACalpha) and PKC (IC50s = 2,100 and >10,000 nM, respectively). Ripasudil (0.4%) reduces intraocular pressure in cynomolgus...
| Schlagworte: | K-115, 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-isoquinoline, monohydrochloride, dihydrate |
| Anwendung: | ROCK1/ROCK2 inhibitor |
| CAS | 887375-67-9 |
| MW: | 395.9 D |
ab 55,00 €
