Zu "882405-89-2" wurden 4 Artikel gefunden!
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BBT594
Artikelnummer: Cay41359-10
BBT594 is an inhibitor of Bcr-AblT315I (IC50 = 44 nM), a form of the Bcr-Abl fusion protein containing a tyrosine-to-isoleucine substitution at position 315. It decreases proliferation in mouse Ba/F3 hematopoietic cells expressing Bcr-AblT315I (GI50 = 117 nM). BBT594 (1 or 5 µM) also inhibits phosphorylation of Jak2...
| Schlagworte: | NVP-BBT594,... |
| Anwendung: | Bcr-AblT315I inhibitor |
| CAS | 882405-89-2 |
| MW: | 569.6 D |
ab 67,00 €
BBT594
Artikelnummer: TGM-T7418-100mg
Description: BBT594 (NVP-BBT594)(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer. Target: c-RET. Smiles: CN1CCN(Cc2ccc(NC(=O)N3CCc4cc(Oc5cc(NC(C)=O)ncn5)ccc34)cc2C(F)(F)F)CC1. References: Zhang Q , Shi C , Han L , et al. Inhibition of mTORC1/C2 signaling improves anti-leukemia...
| Schlagworte: | NVP-BBT594 |
| Anwendung: | Potent PLK4 inhibitor |
| CAS | 882405-89-2 |
| MW: | 569.58 D |
ab 37,00 €
CFI-400437
Artikelnummer: SYN-1207-M100
CFI-400437 is a potent PLK4 inhibitor (IC50=0.6nM) and selective against other members of the PLK family (>10µM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB-231 cell growth and very effective in a mouse xenograft...
| Schlagworte: | (E)-5-Methoxy-3-((3-((E)-2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)vinyl)-1H-indazol-6-yl)methylene)indolin-2-one... |
| Anwendung: | Potent PLK4 inhibitor |
| CAS | 882405-89-2 |
| MW: | 565.5 D |
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BBT594
Artikelnummer: SYN-1225-M001
BBT594 (NVP-BBT594) is a potent and selective inhibitor of RET and JAK2. BBT594 impairs "glial-derived neurotrophic factor" (GDNF)-RET signaling and GDNF-dependent growth in specific in vitro models. Direct inhibition of GDNF-RET signaling by BBT594 in ER+ breast cancer cells enhances the sensitivity to aromatase...
| Schlagworte: | BBT-594 |
| Anwendung: | Potent, selective RET / JAK2 inhibitor |
| CAS | 882405-89-2 |
| MW: | 569.6 D |
ab 250,00 €
