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KU-0060648
Artikelnummer: TGM-T6557-100mg
Description: KU-0060648 is a dual inhibitor of DNA-PK and PI3Kalpha, PI3Kbeta, PI3Kdelta with IC50 values of 8.6 nM, 4 nM, 0.5 nM, and 0.1 nM respectively, and demonstrates less inhibition of PI3Kgamma with an IC50 of 0.59 µM. Target: mTOR, PI3K, DNA-PK. Smiles:...
| Schlagworte: | KU0060648 |
| Anwendung: | Dual PI3K & DNA-PK inhibitor |
| CAS | 881375-00-4 |
| MW: | 582.71 D |
ab 55,00 €
Ku-0060648
Artikelnummer: Cay15344-5
Ku-0060648 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) and an inhibitor of PI3K. In a cell-free assay, it has IC50s of 5, 4, 0.5, 50s of 19 and 39 nM, for DNA-PK and PI3K, respectively, while in SW620 cells, it has an IC50 of 170 nM for DNA-PK but >10,000 nM for PI3K. Ku-0060648 is...
| Schlagworte: | 4-ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide |
| Anwendung: | Dual PI3K & DNA-PK inhibitor |
| CAS | 881375-00-4 |
| MW: | 582.7 D |
ab 52,00 €
