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AZ 628
Artikelnummer: TGM-T6318-100mg
Description: AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. Target: Apoptosis, Raf. Smiles: Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1Nc1ccc2ncn(C)c(=O)c2c1. References: Khazak V, et al. Expert Opin Ther Targets....
| Anwendung: | Raf inhibitor |
| CAS | 878739-06-1 |
| MW: | 451.52 D |
ab 40,00 €
AZ 628
Artikelnummer: Cay15336-1
The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and other types of cancer but is poorly targeted by many...
| Schlagworte: | 3-(1-cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-benzamide |
| Anwendung: | Raf inhibitor |
| CAS | 878739-06-1 |
| MW: | 451.5 D |
ab 44,00 €
AZ628
Artikelnummer: LKT-A9662.1
AZ628 is a potent inhibitor for wild-type c-Raf and b-Raf
| Schlagworte: | 3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide |
| Anwendung: | c-Raf / b-Raf inhibitor |
| CAS | 878739-06-1 |
| MW: | 451.52 D |
ab 172,00 €
