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LOC14
Artikelnummer: TGM-T5534-100mg
Description: LOC14 to be the most potent PDI inhibitor reported to date( EC50 : 500 nM). Target: Others. Smiles: O=C(C1CC1)N1CCN(Cn2sc3ccccc3c2=O)CC1. References: Kaplan A, et al. Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proc Natl Acad Sci U S A. 2015 Apr 28,112(17):E2245-52.
| Anwendung: | PDI inhibitor |
| CAS | 877963-94-5 |
| MW: | 317.41 D |
ab 43,00 €
LOC14
Artikelnummer: Cay17766-10
LOC14 is an inhibitor of protein disulfide isomerase (PDI, Kd = 62 nM). It inhibits PDI chaperone activity in an insulin aggregation assay when used at a concentration of 75 µM. LOC14 reduces PC12 cell death induced by the misfolded huntingtin protein mHTTQ103 (EC50 = 500 nM). It reduces medium spiny neuron (MSN)...
| Schlagworte: | 2-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one |
| Anwendung: | PDI inhibitor |
| CAS | 877963-94-5 |
| MW: | 317.4 D |
ab 128,00 €
