Zu "877636-42-5" wurden 2 Artikel gefunden!
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ML221
Artikelnummer: TGM-T4390-100mg
Description: ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 µM in the cAMP assay, and 1.75 µM in the beta-arrestin assay, and EC80 of 10 nM in both assays. Target: Apelin receptor, Arrestin. Smiles:...
| Anwendung: | Apelin receptor (APJ) antagonist |
| CAS | 877636-42-5 |
| MW: | 385.35 D |
ab 49,00 €
ML-221
Artikelnummer: Cay27313-5
ML-221 is an antagonist of the G protein-coupled receptor (GPCR) APJ (IC50 = 4.8 µM). It is selective for APJ over the angiotensin II type 1 (AT1) receptor (IC50 = >78 µM). ML-221 antagonizes apelin 13-induced activation of APJ in cAMP and beta-arrestin recruitment assays (IC50s = 0.7 and 1.75 µM, respectively). It...
| Schlagworte: | 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one |
| Anwendung: | Apelin receptor (APJ) antagonist |
| CAS | 877636-42-5 |
| MW: | 385.4 D |
ab 90,00 €
