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PF-01247324
Artikelnummer: TGM-T4490-100mg
Description: PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker [IC50: 196 nM]. Target: Sodium Channel. Smiles: CNC(=O)c1ccc(c(N)n1)-c1cc(Cl)cc(Cl)c1Cl. References: Payne CE, et al. A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and...
| Anwendung: | NaV1.8 channel blocker |
| CAS | 875051-72-2 |
| MW: | 330.6 D |
ab 66,00 €
PF-01247324
Artikelnummer: Cay22111-1
PF-01247324 is a blocker of the tetrodotoxin-resistant (TTX-R) sodium channel Nav1.8 (IC50 = 0.19 µM for human Nav1.8). It is selective for Nav1.8 over Nav1.1, Nav1.2, Nav1.5, and Nav1.7 channels (IC50s = 13, 12.8, 9, and 19 µM, respectively) as well as ether-a-go-go (ERG) potassium channels (IC50 = 30 µM)....
| Schlagworte: | 6-amino-N-methyl-5-(2,3,5-trichlorophenyl)-2-pyridinecarboxamide |
| Anwendung: | NaV1.8 channel blocker |
| CAS | 875051-72-2 |
| MW: | 330.6 D |
ab 44,00 €
